subject: Asacol: Used in Treating Ulcerative Colitis [print this page] Asacol: Used in Treating Ulcerative Colitis
Asacol is the trade name of the generic drug Mesalamine also known as (5- aminosalicylic acid). Asacol is mainly used in the treatment of ulcerative colitis. Ulcerative colitis is a serious condition whose cause is unknown and it affects the colon and the rectum by eroding its epithelium and causing ulcers.
The erosion of the colon and rectum is due to the inflammation and further on this leads to formation of ulcers which damage the colon and the rectum permanently. Ulcerative colitis together with Crohn's disease is termed as inflammatory bowel disease.
Exact mechanism of the mode of action of Asacol is not known, however, it is believed that this drug reduces the inflammation and hence treats ulcerative colitis. The inflammation is due to the secretion of chemicals called prostaglandins. These are responsible for the inflammation produced in the colon and the rectum. These prostaglandins are the result of enzymes cyclooxygenase and lipoxygenase. These enzymes are blocked by Asacol. Therefore the production of prostaglandins is greatly reduced and inflammation is also reduced subsequently.
Asacol is a prescription drug and is available in the form of tablets, capsules and suppositories. These tablets and capsules are used in the treatment of mild to moderate ulcerative colitis while the rectal suppositories are used in treating ulcerative colitis of the rectum. The therapy extends from 3 to 21 days and one need to complete the entire course to have maximum effect of the medication.
The side effects of Asacol are dizziness, bloating, gas, belching, minor stomach ache and indigestion. In case of any side effects or allergies observed the physician should be consulted immediately. This is a prescription drug and should be kept away from the reach of children. In case the patient misses or skips a dose, he or she shouldn't double the dose. The dosage should not be increased or decreased without the consultation of the physician.
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