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subject: Russia issued a new medical surgical suture LUO - 4D Theater System - 3D/4D Driving Flight Simulator [print this page]


Russia issued a new medical surgical suture LUO - 4D Theater System - 3D/4D Driving Flight Simulator

At present, Russia is still the majority of medical surgical suture line by twisting and weaving, and their surface is not smooth enough, easy to sew the wound and trauma friction. The international community has already conducted research on polymer impregnated surgical suture or polymer coating, that is suture surface with polymer solution or polymer dispersion by treatment, the treated sutures not only smooth application, but also a certain biological activity, play a pain, bleeding, antibacterial and other effects.

The All-Russian Research Institute of synthetic fiber and other units of experts, drawing on patent documents, based on surgical suture for the modification of Russian research and put forward their views and make a series of technology experiments, are introduced to our country peers:

Modification of surgical suture, using polymer impregnation better grasp of this law to facilitate impregnation layer thickness, to preserve the original Core line of physical and mechanical nature, but also given to biological activity of the outer cores. Modification of surgical sutures to meet the following requirements: the use of the polymer should be non-toxic, its out in the living organism is also non-toxic; polymer solution, non-toxic, volatile; polymer molecular weight and chemical structure must be formed impregnated layer of strength and flexibility, and to adhere to the surgical suture, the suture but will not affect the necessary sterilization.

The polymer impregnated surgical suture layer, if you want to have biological activity, a pharmaceutical carrier, to have the following properties: polymer impregnation to the impregnating layer formed after the pharmacy has to be with good compatibility; impregnated layer itself to have a certain moisture absorption, in order to facilitate transmission of pharmaceutical to the wound; impregnated layer to be able to maintain the pharmacy in which some of the content and validity.

To achieve these multiple requirements, the research on the dipping solution is very important. Russia is using the information recorded in ethanol with copolyamide solution.

Monomer is -caprolactam homopolymer and hexamethylene diamine condensation product of adipic acid in the copolymer ratio of 60:40 between the two. Fat - aromatic copolyamide to -caprolactam and the basis of aromatic dicarboxylic acid containing cationic gene-SO3H, presented with aromatic and difficult to free rotation of the carbonyl gene distribution, full hamper the formation of hydrogen links, which made the melting point down lower crystallinity. The role of the lipid chain copolymer aromatic ring, which will give aromatic chain disorder in lipid distribution, destroy its integrity, and hinder the crystallization of polymers. Amorphous phase increases, so that the speed, such as water vapor permeability, elongation, resistance to rupture and other performance increases, then the elastic properties of amorphous polymer crystallization and the crystallization half time than higher. Increase the molecular structure of the disorder, will be able to reduce the melting point to reduce the intermolecular interaction. Polymer chain segments to increase exercise to make them close to the solvent of the disorder, close to the ion activity linked to increase the solubility of polyamide and reactivity. Ethanol with copolyamide impregnated surgical suture, can be with adhesive, moisture absorption, ion activity of the impregnated layer. If the impregnating solution preservatives, antibiotics or other effective material, can make use of ionic exchange process to pharmaceutical fixation in surgical suture impregnated layer, play a role in biological activity. Because most of the major types of medical pharmaceutical organic cation salt and inorganic acid, so use with ion activity, carboxyl and sulfonic acid containing polymer, can achieve the best results.

All-Russian Research Institute of synthetic fiber expert, the main ingredients for a detailed analysis of impregnating solution, and surgical sutures Making Process Study. They used different copolyamide comparative analysis of two-component polyamide (component -caprolactam, adipic acid hexamethylene diamine, the ratio of 60:40), three components of polyamide (Composition 42% caprolactam, adipic acid 28% hexanediamine, 30% "Kexifuge" salt ). In order to assess the performance of polyamide, set the following indicators: the solution viscosity, melting temperature, end carboxyl group content, moisture absorption, the three components of the sulfur content of polyamide, the theory of exchange capacity, total polyamide adhesive layer attached to power, a total physical and mechanical properties of polyamide layer (breaking strength and elongation), modified suture toxicity.

Impregnated layer strongly affect the performance of one of the factors is the molecular weight, in the actual process, the main rely on to determine the relative viscosity of polymer solution, because the molecular weight and relative viscosity values exist between the corresponding relations. Experimental determination of the relative viscosity of the solution: a total of two-component polyamide 2.30, polyamide 1.80 a total of three components. Experimental results show the optimal low-viscosity copolyamide can improve their end of the content of ionized groups, especially the content of carboxyl groups, help impregnated layer suture fixation agents, and the herbs of slow release.

A total of two-component polyamide melting temperature of 168 , the three components of copolyamide melting temperature of 129 , both higher than that homopolymer - Polyamide 6, low melting temperature of 223 are the first two lower the crystallinity.

A total of two-component polyamide 25 , moisture 15% moisture absorption of three components of polyamide 25 , 16.6%, compared with 11% polyamide 6, have increased.

The amorphous nature of a copolyamide it in the water - ethanol solution (80% ethanol) in the solubility. Preparation of the alcohol solution in a total of polyamide mechanical indicators:

Adhesion breaking strength elongation strength

A total of two-component 270% polyamide 1.1 kg force of 110 Newton meters, a total of three components in polyamide 0.7 kg capacity 85 Nm 280%

Solution impregnated polyamide suture preliminary experiment, in the solution of polyamide content increases from 1-3%, will not lower the suture strength and the "surgical knot" powerful, low-concentration solution of two layers of coating, the ( The first layer is 1%, the second layer of 2%) also slightly increased suture strength. However, to increase the concentration of polyamide, the lower suture strength. At this time the nature of impregnated suture close to the nature of monomers, suture surface slippery. This has consulted with the surgeon and they said that high concentrations of polyamide impregnated suture operational level to drop, bending, poor surgical knot easy to slide open.

Suture on the impregnated layer, visual observation is the uniform, did not observe simultaneous cracking and spalling. Comparative analysis: two-component polyamide suture dipping layers were strong and good flexibility in the three components of polyamide suture dipping layer; its agents as chemical adsorption of the three components of polyamide suture dipping layer.

Solution of polymer in ethanol was found, the solution containing 5% of the total polyamide, room temperature 8 hours or more may remain stable, they can be used for impregnation process of the suture.

Toxicological tests carried out to prove that their products were toxic polyamide.




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