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subject: 2018 Leukemia Therapeutics Market Share To Strong Late-stage Pipeline To Sustain Branded Drugs [print this page]


While some areas of the leukemia drugs pipeline are showing promise, the therapeutics market must also focus on reducing the number of people being misdiagnosed as to their particular type and subtype of the disease in order to move forward, a new report published by business intelligence provider GBI Research says.

The revenue of the leukemia treatment market has increased at a Compound Annual Growth Rate (CAGR) of 21% during the past eight years, due to the launch of new therapies including Sprycel (dasatinib), Tasigna (nilotinib), Clolar (cloferabine) and Arranon (nelarabine), which will continue to enjoy patent protection throughout the next six years covered by the reports forecast period.

The leukemia therapeutics market last year was dominated by branded drugs such as Gleevec (imatinib), Tasigna, Clolar and Arranon with a market share of 85%, while generics such as vincristine, doxorubicin, methotrexate and cytarabine accounted for the remaining 15% share.

During late 2011, the R&D pipeline for leukemia therapeutics had roughly 1,415 clinical trials in various stages of development, including several late stage first-in-class molecules soon expected to be launched. As Acute Myelogenous Leukemia (AML) therapeutics accounted for 43% of the leukemia drug development pipeline, the report predicts a future improvement on the lack of treatment options and correspondingly high mortality rate associated with this disease at present.

However, the report also notes that the risk of misdiagnosis may be an obstacle for the future development of the leukemia market. As leukemia exists in four different types and 50 subtypes, each having a unique genetic signature and requiring different prognosis and treatment, diagnostic tests for leukemia are expensive and inaccurate, with around 50% of all patients misdiagnosed as per their exact subtype of the disease. While new techniques allow for the analysis of all 400 genes that are known to be causes of leukemia in order to find which corresponds to different subtypes, achieving accurate diagnosis remains a challenge and may prove to be a significant obstacle for the leukemia therapeutics market to overcome.

In 2011, the leukemia therapeutics market for four major leukemia indications was estimated at $4 billion, indicating a CAGR of 21.0% since 2004. RnR Market Research forecasts the market to grow at a CAGR of 9.5% between 2011 and 2018 to reach to $7.6 billion by 2018.

Leukemia Therapeutics Market to 2018 - Strong Late-stage Pipeline to Sustain Branded Drugs' Major Market Share report provides an in-depth analysis of the major leukemia indications including acute lymphocytic leukemia (ALL), chronic lymphocytic leukemia (CLL), acute myelocyticleukemia (AML) and chronic myelocyticleukemia (CML). It examines the global leukemia diseases treatment usage patterns. In addition, the geographical distribution of leukemia therapeutics and markets across the US, the top five countries of Europe and in Japan are provided in the report. The report also includes insights into the leukemia therapeutics R&D product pipeline and explores the competitive landscape including major players in the leukemia therapeutics market. Finally, the report also includes analysis on Mergers and Acquisitions (M&As) and licensing agreements that took place in leukemia therapeutics market.

Table of Contents

1 Table of Contents 5

1.1 List of Tables 8

1.2 List of Figures 10

2 Leukemia Market to 2018 - Introduction 12

3 Leukemia Market to 2018 - Market Overview 13

3.1 Introduction 13

3.1.1 Revenue 13

3.1.2 Annual Cost of Treatment 15

3.1.3 Treatment Usage Pattern 16

3.2 Drivers and Barriers 18

3.2.1 Drivers for the Leukemia Therapeutics Market 18

3.2.2 Barriers for the Leukemia Therapeutics Market 19

4 Leukemia Market to 2018 - Geographical Landscape 20

4.1 Revenue Analysis by Geography 20

4.2 The US 22

4.2.1 Revenue 22

4.2.2 Annual Cost of Therapy 23

4.2.3 Treatment Usage Pattern 24

4.3 Top Five Countries of Europe 26

4.3.1 Revenue 26

4.3.2 Annual Cost of Therapy 28

4.3.3 Treatment Usage Pattern 30

4.4 Japan 32

4.4.1 Revenue 32

4.4.2 Annual Cost of Therapy 33

4.4.3 Treatment Usage Pattern 34

5 Leukemia Market to 2018 - Therapeutic Landscape 36

5.1 Acute Lymphocytic Leukemia (ALL) Therapeutics Market 36

5.1.1 Introduction 36

5.1.2 Classification 37

5.1.3 Epidemiology 38

5.1.4 Signs and Symptoms 39

5.1.5 Treatment and Management Pattern 40

5.1.6 Revenue 41

5.1.7 Annual Cost of Treatment 46

5.1.8 Treatment Usage Pattern 47

5.1.9 Major Marketed Products 49

5.1.10 Drivers and Barriers for the ALL Therapeutics Market 51

5.2 Chronic Lymphocytic Leukemia Therapeutics Market 52

5.2.1 Introduction 52

5.2.2 Epidemiology 53

5.2.3 Symptoms 53

5.2.4 Diagnosis 53

5.2.5 Treatment 55

5.2.6 Revenue 56

5.2.7 Annual Cost of Treatment 60

5.2.8 Treatment Usage Pattern 61

5.2.9 Major Marketed Products 63

5.2.10 Drivers and Barriers for the CLL Therapeutics Market 65

5.3 Acute Myelogenous Leukemia Therapeutics Market 66

5.3.1 Introduction 66

5.3.2 Epidemiology 68

5.3.3 Symptoms 68

5.3.4 Staging of AML 69

5.3.5 Diagnosis 69

5.3.6 Treatment by Stage 71

5.3.7 Revenue 72

5.3.8 Annual Cost of Treatment 76

5.3.9 Treatment Usage Pattern 77

5.3.10 Major Marketed Products 79

5.3.11 Drivers and Barriers for the AML Therapeutics Market 80

5.4 Chronic Myelogenous Leukemia Therapeutics Market 82

5.4.1 Introduction 82

5.4.2 Epidemiology 82

5.4.3 Staging 83

5.4.4 Symptoms 83

5.4.5 Diagnosis 84

5.4.6 Treatment of CML 84

5.4.7 Revenue 85

5.4.8 Annual Cost of Treatment 90

5.4.9 Treatment Usage Pattern 91

5.4.10 Major Marketed Products 93

5.4.11 Drivers and Barriers for the CML Therapeutics Market 96

by: RnR Market Research




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