subject: Imitrex nasal spray [print this page] Imitrex, generic name (Sumatriptan) is a nasal spray that contains Sumatriptan. Sumatriptan on the other hand is a white powder that has high level of solubility especially in water and other solvents like saline. It is a chemically designed substance that has the empirical formula of C14H21N302S.
Sumatriptan, being agonistic to the vascular 5-hydroxytryptamine 1 receptor has only weak affinity for 5-HT 1A and other HT receptor subtypes.
The vascular 5-HT 1 subtypes that are subject to activation by Sumatriptan are only present in the arteries that are present in the skulls of both dogs and other canines and primates. The basilar artery and the vasculature of the dura matter of the human contain the vascular 5-HT 1 receptor subtypes and act as a go-between for vasoconstriction. In addition to being responsible for vasoconstriction, there has been conclusion based on data collected from experiments on animal and other animal studies to point out that Sumatriptan also has the ability to activate 5-HT 1 receptors that are found on the nonessential terminals of the body's trigeminal nerve innervating blood from the vessels of the skull.
According to experiments that were carried out to determine the efficiency of Imitrex nasal spray as can be used in treatment of acute migraines, 8 studies were carried out in which 5 out of the total had used the recommended dosing and had the marketing formula. A majority of the patients that participated (86%) were female and posted an average age of 41 years (This was between the ages of 18 to 65) The instruction was to treat headaches of different magnitudes. The responses that were given differed from patient to another. They were defined either as severe to mild, or mild to no pain.
Symptoms associated to medications were also studied during the experiment. These included side effects such as nausea and photophobia.
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