subject: Hemorrhoids and Varicose Veins: A Review of Treatment Options [print this page] Daflon 500 mgDaflon 500 mg. Bioflavonoids, particulary diosmin, oligomeric proanthocyanidin complexes (OPCs), and hesperidin, have showed effectiveness in the treatment of hemorrhoids and varicose veins. These bioflavonoids show phlebotonic action, vasculoprotective effects, and antagonism of the biochemical mediators of inflammation. OPCs, diosmin, and hesperidin have been the main topic of several clinical trials on efficacy and safety in the treatment of varicose veins and hemorrhoids.
There has been extensive research on the flavonoid mixture containing 90-percent diosmin and 10-percent hesperidin (Daflon 500, Les Laboratories, Servier, France). Several randomized controlled studies have established its efficacy in the treatment of varicose veins and hemorrhoids. The safety of these flavonoids has been established as a result of animal scientific studies, and affirmed clinically in long-term trials. Info collected on greater than 2,850 patients treated with 450 mg diosmin and 50 mg hesperidin twice daily for approximately twelve months confirms it's well tolerated and has no contraindications to its use. Side effects are uncommon and mild with an incidence and nature a lot like that found with placebo in double-blind, controlled trials.
A double-blind, placebo-controlled trial of 120 sufferers reported the efficacy of Daflon in the treatment of acute and constant symptoms of hemorrhoids. The group was separated in half and matched at entry for standard characteristics, clinical features, length of history, and acute episodes. Sufferers got the flavonoid mixture at a dose of two 500 mg pills daily or placebo for 2 months. Subjects were evaluated on pain, pruritis, discharge, bleeding, edema, erythema, and bleeding on examination. Mean parameter scores and overall symptom results fell drastically in the treated group. Much the same double-blind, placebo-controlled analysis analyzed 100 individuals suffering an acute hemorrhoid attack. These individuals received Daflon in a loading amount of three 500 mg tablets two times a day for the first 4 days and two pills twice a day the following three days. The clinical severity of proctorrhagia, anal discomfort, ache, and anal discharge diminished to a greater extent in the treatment group.
Hemorrhoids and Varicose Veins: A Review of Treatment Options
