subject: Dermal Fillers for lines and wrinkles [print this page] The results of Dermal Fillers can last from three months to five years, depending on the filler being used. Location can also affect the duration of results, for example, fillers tend to provide results that last significantly less time in the lips (3 to 6 months), compared to nasolabial folds. Collagen based products typically provide the shortest duration of results. Hyluronic acid based fillers tend to endure for longer, with effects usually lasting from six months to one year. Products like Sculptra is long-lasting, because it actually works by activating the production of natural collagen which fills the wrinkle or fold over time (usually 2 to 6 months), rather than plumping the area with the product itself. Since it works in this way, Sculptra is not technically classified as a dermal filler, but it is administered similarly to one and the results can last up to two years.