AN EVALUATION OF GENOTOXIC EFFECTS OF RIBAVIRIN IN BONE MARROW ERYTHROCYTE CELL LINES BY MICRONUCLEUS ASSAY IN ALBINO RATS

Human Immunodeficiency Virus I (HIV-I) transmission duringpregnancy is highly complex

and a variable process due to theexpression of several anti-HIV factors. In this study, we haveanalyzed the anti-HIV activity of a pregnancy-associated protein(Pap-1) present in placental tissue as well as in urine of pregnantwomen during their first trimester. Based on the observation thatleupeptin inhibit the activity of Pap-1, a leupeptin-binding proteinpart (Pap-1a) was purified from Pap-1. It is found that the purifiedPap-1a can inhibit HIV-1 IIIB/HUT 78 infection. The molecularanalysis of the action of Pap-1m showed that the anti-HIV activityis due to its action on HIV-CD4 binding through inhibition of CD4-gp 160 interaction. Based on the characterization of Pap-1 andPap-1a, a mechanism for their association and their action onHIV-1 infection was discussed.

AN EVALUATION OF GENOTOXIC EFFECTS OF RIBAVIRIN IN BONE MARROW ERYTHROCYTE CELL LINES BY MICRONUCLEUS ASSAY IN ALBINO RATS

By: Dr Izharul Hasan

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