Antibody Sequencing Applications

Fusion Antibodies proprietary FET (Fusion Expression Technology) is rapid and reliable

. The multi-parallel screening approach utilises several proprietary vector systems for accelerating the production of recombinant protein you require. Later, Bioinformatics is applied for designing the most suitable proteins necessary for individual research projects. Be it drug development, patent application, DNA sequencing, cloning, etc. We fulfil your project requirements in a timely and cost-efficient manner. Our sequencing process effectively humanises murine monoclonal anti-bodies with the help of advanced strategies developed specifically to reduce the HAMA (Human Anti-Mouse Anti-body) response in patients undergoing antibody therapy. We have worked with hundreds of biotech companies consistently delivering high quality results even on extremely challenging projects. Our organisation is a UK-based CRO providing ISO 9001:2000 accredited services in all aspects of therapeutic and diagnostic anti-body development to researchers around the world. From the biggest pharma-company to the smallest biotech firm, they provide customises world-class services that best suit various research requirements.

The medical research faculty oftentimes requires several proteins and non-protein coding genes for researching on various viral, bacterial, fungal parasites, yeast, baculovirus/insect, and mammalian cells as the process of gene expression is used by all known microbial life. Such as, eukaryotes (including multi-cellular organisms), prokaryotes (bacteria and archaea), in which it is possibly induced by viruses for generating the macromolecular machinery for life. The study of these microorganisms is necessary for understanding the fundamental building blocks of protein-structures, their functions, their mechanism, growth, development, and life cycles. Moreover, non-protein coding genes such as ribosomal RNA (rRNA), transfer RNA (tRNA) or small nuclear RNA (snRNA) genes, the product is a functional RNA, which necessitates protein sequencing. Several steps in a gene expression process, too, require modulation such as the transcription, RNA splicing, translation, and post-translational modification of a protein.

Monoclonal Antibodies are also extensively used in the radioimmunodetection and radioimmunotherapy of cancer amongst which, certain new methods can even target only the cell membranes of cancerous cells. Several diagnostic tests used for determining small amounts of drugs, toxins or hormones, e.g. these are used in pregnancy test kits, which require the presence of anti-bodies. From many other more known diagnostic processes or methodologies, which use these, is the diagnosis of AIDS by the ELISA test. The problem of organ rejection in patients, who have had organ transplants, has seen successful treatments developed is called as OKT3, which is an anti-body to the T3 antigen produced by T cells of the human immune mechanism. A strain of single pathogen such as Neisseria gonorrhoeae have been successfully classified using this methodology of sequencing. Quite a few traditionally considered "untreatable" viral diseases have found solutions developed using this process. At the pace at which current clinical research is leaping ahead, several research specialists hold the opinion that it could be an important tool in the race to defeat HIV virus, and cure AIDS. These are required in various academic, medical and commercial applications, especially clinical research. Monoclonal antibodies are usually produced in non-human species, mainly rats and mice. However, the human immune system can recognize them as foreign leading to less desirable results.

by: Paul Kerr

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