Anticipated Impact Of Vaccination
Doctors have noted several important unanswered questions that make it difficult
to predict the actual impact of a vaccine on HPV infection and disease. However, it is possible to give some estimates if it is assumed that the vaccine will provide at least 90% type-specific efficacy, with boosters as necessary to ensure that this protection is of long duration.
Under those circumstances, the greatest short-term impact in industrialized nations such as the United States would be a reduction in the overall number of CIN2 cases to about one-third to one-half as many such lesions in vaccinated women compared with nonvaccinated women, given that HPV16 and HPV18 together account for 60-70% of such lesions.
This protection would translate to a substantial reduction in medical and psychological morbidity and treatment together with a reduction in the related costs. The anticipated eventual reduction in the incidence of cervical cancers and its consequences would be anticipated to be at least as great.
If the vaccine were widely administered to populations that historically are less likely to be screened regularly, the vaccine could prevent most of those serious infections that currently are not detected because of a lack of screening. The impact on subclinical and low-grade dysplasias would be expected to be more modest, as only a minority of these infections are attributable to HPV16 and HPV18.
Although these anticipated reductions in CIN2 and invasive cervical cancer would be impressive, it must be noted that there would still be many serious HPV infections against which the vaccine would not protect. For this reason, it will be essential to educate health care providers and patients about this limitation of the vaccine and to emphasize that it will be necessary for vaccinated women to follow current cervical cancer screening guidelines.
What about vaccination in developing countries, where 80% of cervical cancers occur, but where medical resources are relatively scarce? The vaccine probably has the potential to prevent several hundred thousand cancers annually, many of which affect relatively young women and therefore have an enormous impact on their life expectancies.
However, vaccination in low-resource settings would probably be cost-effective only if the expense of vaccination were modest, especially in view of the long interval between infection and the development of invasive cancer. The history of hepatitis B vaccination suggests that it may take many years to achieve a cost-effective vaccination program in developing areas.
Thus reducing the cost of vaccination would be a priority for the developing world. In the interim, a substantial reduction in the incidence of cervical cancer might be achievable in these settings, in less time than vaccination would lead to a reduction, by the alternate modality of a low-cost once- or twice-in-a-lifetime screen-and-treat approach to cervical cancer prevention.
Most pharmacology efforts now focus on developing a vaccine to inoculate the population in order to stop the HPV virus from infecting the system. This is ideal for the pharmaceutical companies as it would of course reap a monetary windfall of epic proportions for the drug companies, but not useful at all for those already affected with warts.
The medical community has not had success to develop a treatment to successfully eradicate existing infections without causing extensive skin damage, trauma, or relapse. Importantly, China has now banned such vaccinations as they have found injecting a pathogen into your system does just that, it stays in your system, remaining latent in the joints, only to reappear in later years causing horrendous arthritis and or auto immune disorders.
Some of the most impressive results consistently achieved with medicinal plants are in the elimination of warts. AntiWarts-Rx is a potent anti-viral agent for topical use against warts. It inhibits and kills the HPV virus, resulting in fast elimination of warts and wart like substances. The antiviral activities of our antiwarts treatments are well documented and principally due to their direct effect to eradicate the HPV virus.
The antiviral properties in AntiWarts-Rx are highly pronounced and well documented. They quantifiably destroy the HPV virus, thus characterizing AntiWarts-Rx as a potent anti warts agent. As a result, it is no surprise that the antiviral compounds in AntiWarts-Rx are used by drug companies to manufacture pharmaceutical treatments for genital warts, warts, and cancer.
AntiWarts-Rx has a wide spectrum of action against HPV, is non toxic when applied topically, and represents a perfectly safe and effective wart remover. As the product is quickly absorbed into skin tissue without causing harmful side effects, it is ideal for eradicating wart infections. To learn more, please go to http://www.naturespharma.org.
by: bcured
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