Application Of Resveratrol In Cardiovascular Disease

Resveratrol has become one of the focuses in recent years

. A large number of studies have shown that resveratrol has a variety of pharmacological effects, such as anti bacterial anti inflammatory, hepatoprotective and anti cancer. In the cardiovascular system, it has the functions of antioxidant, free radical scavenging, inhibiting platelet aggregation, regulation of blood lipids and preventing arterial atherosclerosis. In addition, researchers found the most effective way for curved cholesterol interference. Mixed red wine with garlic can have anti-cholesterol effect. After a mixture of both, it will play a double utility on bile in the blood shield alcohol. The falconoid can remove the fat which is attached to the artery. Thus it prevents the occurrence of coronary heart disease.

Effects of resveratrol on ventricular K channel resveratrol may affect the open state of the channel and the inhibition of HERG current inactivation state, allowing the myocardial cell repolarization time extended to improve tachyarrhythmia, the HERG channel resveratrol new target for anti-arrhythmic effects. In addition, pharmaceutical raw materials resveratrol can significantly enhance the chronic activation of the delayed rectifier potassium current, and thus action potential, delayed rectifier K + current is increased, fast repolarization of action potential duration shortening the effective refractory period to reduce the dose-dependent manner. For the early after-depolarization-induced torsades de pointes-type arrhythmias may play therapy.

Resveratrol in vitro antioxidant activity and free radical scavenging capacity is low, and showed strong antioxidant activity in the body, mainly through the induction of NO synthesis play a role. Trans-resveratrol can inhibit the induction of Cu of very low density lipoprotein cholesterol peroxidation, further study showed that resveratrol than other polyphenols such as catechin, epicatechin and quercetin inhibit the induction of LDL oxidation is more obvious, mainly from veratryl alcohol has a strong Cu chelating ability. Resveratrol can increase intracellular antioxidant enzymes such as glutathione peroxidase, glutathione reductase levels, enhance cellular antioxidant capacity.

Oxidized LDL can promote endothelial cell apoptosis channel activation, including those associated with the decline of mitochondrial membrane potential and release of cytochrome C-mediated apoptosis. The inhibition of vascular endothelial cell apoptosis may prevent or reduce the occurrence of thrombosis. Resveratrol through a variety of different ways plays the therapeutic efficacy, antipyretic and analgesic activity. Resveratrol does not affect blood pressure gives the gastric mucosal resistance to gastric secretion by suppression of stress ulcer.

With the deepening study of resveratrol, in the pharmaceutical industry, in particular in food industry, resveratrol is more and more widely used. It can also be added to a variety of health wine. Many wine producers regard resveratrol content as one of wine performance standards.Source:http://www.cospcn.com

by: anelwew

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