Asbestos Exposed Groups and Chronic Interstitial Lung Disease
One thing is clear, exposure to asbestos can be fatal
. There are a myriad of studies dedicated to examining the link between exposure and disease development. One interesting study is called, "Asbestos bodies in bronchoalveolar lavage fluid. A study of 20 asbestos-exposed individuals and comparison to patients with other chronic interstitial lung diseases" by Roggli, V.L. ; Piantadosi, C.A. ; Bell, D.Y. Acta Cytol.; (United States); Journal Volume: 5 Here is an excerpt: "We studied the asbestos body (AB) content of bronchoalveolar lavage fluid from 20 patients with a history of occupational asbestos exposure, 31 patients with sarcoidosis and 5 patients with idiopathic pulmonary fibrosis. The cellular lavage pellet was digested in sodium hypochlorite and filtered onto Nuclepore filters for AB quantification by light microscopy. ABs were found in 15 of 20 asbestos-exposed individuals, 9 of 31 sarcoidosis cases and 2 of 5 patients with idiopathic pulmonary fibrosis. There was a statistically significant difference in the number of ABs per million cells recovered or per milliliter of recovered lavage fluid in the asbestos-exposed group as compared to the other categories of chronic interstitial lung disease. The highest levels occurred in patients with asbestosis. Large numbers of asbestos bodies in the lavage fluid (greater than 1 AB/10(6) cells) were indicative of considerable occupational asbestos exposure, whereas occasional bodies were a nonspecific finding."
Another interesting study is called, "Application of Sprayed Inorganic Fiber Containing Asbestos: Occupational Health Hazards" by William B. Reitze; William J. Nicholson; Duncan A. Holaday; Irving J. Selikoff - American Industrial Hygiene Association Journal, Volume 33, Issue 3 March 1972 , pages 178 191. Here is an excerpt: "Abstract
Over 40,000 tons of inorganic fibrous insulation containing asbestos were used in 1970 by the construction industry as a fireproofing material in the erection of multistoried buildings. The application of this material by a spraying technique produces serious contamination of the working environment. Asbestos fiber concentrations may range from 30 f/cc to more than 100 f/cc. Some early observations of the exposures and health of the workmen in this comparatively new occupation are given with photographs of the working areas. Nearby workers may be indirectly exposed. Such concentrations were found to be 70 f/cc ten feet from the spraying and 46 f/cc seventy-five feet away. Control measures are discussed."
A third study is called, "Effect of asbestos on lipid peroxidation in the red cells." By S Gabor, Z Anca - Br J Ind Med 1975;32:39-41. Here is an excerpt: "Abstract -
In vitro exposure of red cells to vie International Union against Cancer (UICC) standard reference asbestos samples resulted in an increase of thiobarbituric acid substances. Chrysotiles developed the largest amounts of lipid peroxides, followed by anthophyllite, amosite, and crocidolite in decreasing order. Compared with the control samples erythrocytes free of dusts, all types of the asbestos examined disclosed significant differences. The results obtained provide support for the cytotoxic potential of amosite and crocidolite and, on the other hand, suggest that a lipid peroxidation of unsaturated fatty acids may be involved in the mechanisms(s) of membrane-damaging effects of asbestos dusts.
Another study is called, "Mineralogic parameters related to amosite asbestos-induced fibrosis in humans." By Churg A, Wright J, Wiggs B, Depaoli L. - Am Rev Respir Dis. 1990 Dec;142(6 Pt 1):1331-6. Here is an excerpt: "Abstract - We have previously shown that in the lungs of a group of chrysotile miners and millers, grade of interstitial fibrosis (asbestosis) is directly proportional to tremolite fiber or chrysotile fiber concentration but is inversely proportional to mean fiber length and length-related parameters. To compare the effects of the commercial amphibole asbestos amosite on parenchymal fibrosis, we histologically graded fibrosis in four different sites in the lungs of 20 shipyard and insulation workers with heavy amosite exposure and measured by analytic electron microscopy fiber concentration and size in corresponding portions of lung tissue. Fibrosis grade was found to be strongly positively correlated with amosite concentration and negatively correlated with mean fiber size parameters, including fiber length, width, surface area, and mass. A comparison of our present results with our data on the chrysotile miners and millers showed that the regression lines of fibrosis grade versus concentration for amosite, chrysotile, and tremolite were statistically different. These findings indicate that amosite concentration, like chrysotile and tremolite concentration, is closely and directly related to fibrosis at the local lung level. Furthermore, these observations again raise the possibility that short fibers may be more important than is commonly believed in the genesis of fibrosis in man. Last, the concentration comparison data indicate that, fiber for fiber, amosite is more fibrogenic than is chrysotile or tremolite, and indirectly suggest that tremolite is more fibrogenic than is chrysotile."
We all owe a debt of gratitude to these fine researchers for their hard work and dedication. If you found any of these excerpts interesting, please read the studies in their entirety.
Asbestos Exposed Groups and Chronic Interstitial Lung Disease
By: Montwrobleski77
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