16-year old Justin Bieber said he's "extremey humblend and honoured" to be part of the show
, which honours the most popular albums and artists.
"As a small-town kid from Canada, I never imagined that I would be nominated for AMA's let alone be performing on the show," he said without hinting at what song he plans to perform.
Ke$ha said she's excited for her "first big American awards-show performance" and humbled to be nominated for artist of the year.
"To have my name nominated alongside them really solidifies the impact I've had on American pop culture and on pop music the past year," she said.
"I'm really honoured and definitely going to cover America in glitter."
Other artists slated to perform at the show include Christina Aguilera, Bon Jovi, Usher and Pink.
The American Music Awards will be presented Nov.21 at the Nokia Theatre and broadcast live on ABC. Music fans can choose the winners by voting online.