Contrave Receives Positive Recommendation from FDA Advisory Committee for Treatment of Obesity

Contrave Receives Positive Recommendation from FDA Advisory Committee for Treatment of Obesity

Contrave is an investigational medication for the treatment of obesity.

With its unique mechanism of action in the CNS, Contrave has the potential to change the way obesity is treatedby:Initiating weight loss by reducing appetite and increasing metabolismAllowing the body to sustain continued weight loss by offsetting its natural tendency to fight back and slowing down the weight loss processAddressing the reward system in the brain that causes food cravingsContrave is a combination of two well-established drugs, naltrexone and bupropion, in a sustained release formulation.The active ingredients of Contrave have been used for over 20 years. Bupropion is a widely-prescribed antidepressant and smoking cessation medication; naltrexone is a treatment for alcohol and opioid addiction. We believe that bupropion helps initiate weight loss while naltrexone may sustain weight loss by preventing the body's natural tendency to counteract efforts to lose weight.Contrave is still in the testing stages, but it seems to offer great promise as a medication that will actually reduce the risk factors associated with obesity. Currently, this drug is in its third stage of clinical trials to assess the "safety, tolerability and efficacy", according to the company website. The company that is responsible for Contrave is Orexigen Therapeuticals, a biopharmaceutical company that is focused on creating drugs that treat central nervous system disorders, including obesity. Current studies are showing that Contrave can effectively reduce metabolic syndrome in many patients. Metabolic syndrome is a combination of risk factors that may increase the incidence of obesity, which can also increase the risk of heart disease and diabetes. This medication takes a whole new approach to weight loss, by focusing on neurological causes of obesity rather than suppressing appetite or altering metabolic function.List of IngredientsThe two main ingredients that are being studied in the Contrave formula include Naltrexone and Bupropion. Naltrexone has been used in the United States to treat opioid addiction since 1984, and in 1995 it began to be used to treat alcoholism as well. This drug inhibits the reinforcement of addictive substances by blocking opioid receptors to the brain, according to the Orexigen website. Naltrexone has also been shown to alter the taste of foods in numerous clinical studies.Bupropion has been used to treat depression since 1985, and in 1997 trials were begun that experimented with the use of Bupropion as an aid to help quit smoking. This drug appears to be effective at suppressing appetite and increasing energy levels, and is the most prescribed antidepressant in the United States at the time of this review. One side effect that has been noted with Bupropion is weight loss; an attractive side effect for many indeed.Product FeaturesSince this medication is still in the clinical trial stage, there are few product features to report. It is suspected that this medication will only be available by prescription, since it contains potent ingredients with potentially dangerous side effects. There is no pricing or customer testimonials at this time; however, ample clinical data is provided on the Orexigen website, and this info is comprehensive and professionally displayed.AdvantagesThe ingredients in Contrave may be effective in suppressing appetite and promoting weight loss. Many clinical studies have been done on this product and are continuing at this time. The company website contains ample information on the developmental progress of this product. DisadvantagesThis product is not yet available to the general public at the time of this review. The ingredients in Contrave may have potentially serious side effects for some. May interact badly with other prescription medications. ConclusionContrave is worth keeping an eye out for, since the initial clinical studies have been promising and plenty of research is being conducted on the product. However, Contrave will not be the right choice for everyone, due to the possible side effects and medication interactions that may occur. Also, it definitely appears that Contrave will be prescription only, and will most likely be used to . It is important to talk to your doctor about whether Contrave would be a good choice for you. http://www.articlesbase.com/supplements-and-vitamins-articles/contrave-receives-positive-recommendation-from-fda-advisory-committee-for-treatment-of-obesity-3811852.html

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