Drugs, High

Innovations in aseptic filling Aseptic filling exciting innovations include blow

molding sealing filling (for large volumetric flask), and forming sealing filling (for a single dose or multiple dose vial). In both cases the Polyethylene Resin squeeze to Mold , Then for aseptic filling, the final product sent.

As for aseptic filling ampoules, usually require a set of separate systems or Class 100 clean room. Both cases have to be at the same time as the bottle sterilization and storage space for the process of leaving. Cover, spacers, stoppers, etc. should be dealt with separately and storage. DeyL.P Corporation (California State Napa City), Senior Vice President Ray Joske said: "a plug Washing machine The price may be as high as 100 million, and requires a long certification cycles. "Because every bottle to go through several steps operations, classification of the treatment area (or isolated system) are large. Molding / blow molding filling and relatively compact with 2 1 100 of Stainless steel "Air-blown shower."

Blowing / molding sealing significantly reduces the complexity of aseptic filling, but the United States Pharmacy Business Quedui out of most products have to suffer when the temperature was unsettled, so the limit of this method of filling Ophthalmology And respiratory medicine. Joske think this is regrettable. In Europe, the filling out of polyethylene business methods commonly used injectable drugs, as well as filling more general ophthalmology and respiratory medicine. Some of Europe's packaging business increased by luer port or spacer, to their products into multi-dose packaging. Joske noted tablet or liquid Preparation Of inhaled quantitative packaging development is a use of blow / molding container strong signal.

Rommelag branch Anke Henke believe the United States: because of the inertia of thinking, on Glass Material more familiar and hate to blow the new filling line certification, the United States in the new plastic materials, innovation and backward than in Europe. But she estimated that Drugs Polymer Containers, sooner or later will see a major breakthrough. "Compared with glass, plastic has many advantages, including easy processing and the column Transport , Lower breakage rate. "She said.

While Henke recognize the "temperature sensitive" drugs may not use the blow - filling method, but she considered the proteins and other drugs are all easy to change the exclusion was a mistake. Because the blow - filling fast, drug just being instantaneous heating, and then was quickly cooled. "After leaving the mold, filling even better drugs that can be immediately frozen." She explained.

Concerned about freeze-drying

If the demand is the mother of innovation, then, freeze-drying brings more than other methods of filling innovation. This approach to peptides, proteins, and many relatively small molecules (such as macrolide Antibiotic ) To bring better stability and shelf life. In the last century, the seventies and eighties entered the production of freeze-drying method, when the drugs that are mainly prescription drugs levels of simple small molecules, and occasionally it may be Vaccine . Today, there are quite a number of biological products into mass production, the application of freeze-drying method began more and more.

Drugs, High

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