Effect Of Resveratrol On Atherosclerosis

Modern pharmacological studies have shown that resveratrol has multiple beneficial effects

, such as the regulation of lipid metabolism, inhibition of LDL oxidation and platelet aggregation, cardiovascular protection, ischemic injury, anti-inflammatory and anti-tumor. Therefore, the protective effect of resveratrol on cardiovascular system is becoming a hot spot.

Resveratrol can inhibit LDL oxidation and protect endothelial cells of oxidized LDL injury. It plays a protective role in early atherosclerosis. The study confirmed that resveratrol can effectively remove the hydroxyl oxygen, peroxides and metal free radicals and protect the lipid peroxidation and DNA damage caused by oxygen free radicals. Resveratrol can weaken the production of oxidized low-density lipoprotein-induced cytotoxicity and reactive oxygen free radicals, reduce the savings of intracellular calcium, inhibition of cytochrome C release and apoptotic protein caspase 3 activity, thereby protecting oxLDL injury endothelial cells.

It is found that resveratrol can inhibit lipopolysaccharide-induced expression of VCAM-1, and can prevent monocyte adhesion to endothelial cells. Resveratrol diminished STAT3 phosphorylation inhibition of interleukin-induced ICAM-1 gene expression. Studies have shown that resveratrol and glutathione have inhibitions in transplanting human saphenous vein endothelial VCAM-1 and ICAM-1 expression, and prevent neutrophil adhesion to endothelial cells.

Advanced glycation end products can contribute to stroke-prone spontaneously hypertensive rats and Wistar-Kyoto rats, vascular smooth muscle cell proliferation and a concentration and time dependent manner, while resveratrol can significantly inhibit the SHRSP of VSMC proliferation, as well as DNA synthesis and secondary aminoacyl-hydroxylase activity. Resveratrol can inhibit the expression of transforming growth factor gene.

Resveratrol is a phytoestrogen, can combine with estrogen receptor in the human body and play estrogen-like effects, so for the cardiovascular system may have estrogen-like protective effect. Resveratrol may be associated with the ER signal rapid activation of the anti-atherosclerotic role of resveratrol promote eNOS gene expression can not be blocked by the ER antagonist, on isolated pig coronary vasodilation has not been the ER antagonist impact. Resveratrol is mainly in the fast activated by non-genetic means ER play an estrogen-like protective effect.

Resveratrol and its derivatives are a class of plant polyphenols studied by many scientists in recent years. Their anti-atherosclerotic role has gradually become a hot topic. But mechanisms of chia seed and it are far from clear, such as the effect of resveratrol on the ion channels, as well as the exact signal transduction pathway and how does the relationship of dose against atherosclerosis. They all need further study. With in-depth study of resveratrol and its derivatives. It can be expected to open up new ideas for drug development in the prevention and treatment of atherosclerotic disease.

by: anelwew

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