Endocrine Gland - China Foot Splint - Arm Splint
Chemistry
Chemistry
Most hormones are steroid- or amino acid-based. Hormones alter cell activity by stimulating or inhibiting characteristic cellular processes of their target cells.
Cell responses to hormone stimulation may involve changes in membrane permeability; enzyme synthesis, activation, or inhibition; secretory activity; gene activation; and mitosis.
Second-messenger mechanisms employing intracellular messengers and transduced by G proteins are a common means by which amino acidased hormones interact with their target cells. In the cyclic AMP system, the hormone binds to a plasma membrane receptor that couples to a G protein. When the G protein is activated it, in turn, couples to adenylate cyclase, which catalyzes the synthesis of cyclic AMP from ATP. Cyclic AMP initiates reactions that activate protein kinases and other enzymes, leading to cellular response. The PIP-calcium signal mechanism, involving phosphatidyl inositol, is another important second-messenger system. Other second messengers are cyclic GMP and calcium.
Steroid hormones (and thyroid hormone) enter their target cells and effect responses by activating DNA, which initiates messenger RNA formation leading to protein synthesis.
You do not include the pineal gland in your list of endocrine glands even though it is indicated on your chart to the right.
Target cell specificity
The ability of a target cell to respond to a hormone depends on the presence of receptors, within the cell or on its plasma membrane, to which the hormone can bind.
Hormone receptors are dynamic structures. Changes in number and sensitivity of hormone receptors may occur in response to high or low levels of stimulating hormones.
Blood levels of hormones reflect a balance between secretion and degradation/excretion. The liver and kidneys are the major organs that degrade hormones; breakdown products are excreted in urine and feces.
Hormone half-life and duration of activity are limited and vary from hormone to hormone.
Interaction of hormones at target cells
Permissiveness is the situation in which a hormone cannot exert its full effects without the presence of another hormone.
Synergism occurs when two or more hormones produce the same effects in a target cell and their results are amplified.
Antagonism occurs when a hormone opposes or reverses the effect of another hormone.
Control of hormone release
Endocrine organs are activated to release their hormones by humoral, neural, or hormonal stimuli. Negative feedback is important in regulating hormone levels in the blood.
The nervous system, acting through hypothalamic controls, can in certain cases override or modulate hormonal effects.
Major endocrine organs
Pituitary gland (hypophysis)
Main article: Pituitary gland
The pituitary gland hangs from the base of the brain by a stalk and is enclosed by bone. It consists of a hormone-producing glandular portion (anterior pituitary) and a neural portion (posterior pituitary), which is an extension of the hypothalamus. The hypothalamus regulates the hormonal output of the anterior pituitary and synthesizes two hormones that it exports to the posterior pituitary of storage and later release.
Four of the six adenohypophyseal hormones are tropic hormones that regulate the function of other endocrine organs. Most anterior pituitary hormones exhibit a diurnal rhythm of release, which is subject to modification by stimuli influencing the hypothalamus.
Somatotropic hormone or Growth hormone (GH) is an anabolic hormone that stimulates growth of all body tissues but especially skeletal muscle and bone. It may act directly, or indirectly via insulin-like growth factors (IGFs). GH mobilizes fats, stimulates protein synthesis, and inhibits glucose uptake and metabolism. Secretion is regulated by growth hormone releasing hormone (GHRH) and growth hormone inhibiting hormone (GHIH), or somatostatin. Hypersecretion causes gigantism in children and acromegaly in adults; hyposecretion in children causes pituitary dwarfism.
Thyroid-stimulating hormone (TSH) promotes normal development and activity of the thyroid gland. Thyrotropin-releasing hormone (TRH) stimulates its release; negative feedback of thyroid hormone inhibits it.
Adrenocorticotropic hormone (ACTH) stimulates the adrenal cortex to release corticosteroids. ACTH release is triggered by corticotropin-releasing hormone (CRH) and inhibited by rising glucocorticoid levels.
The gonadotropinsollicle-stimulating hormone (FSH) and luteinizing hormone (LH) regulate the functions of the gonads in both sexes. FSH stimulates sex cell production; LH stimulates gonadal hormone production. Gonadotropin levels rise in response to gonadotropin-releasing hormone (GnRH). Negative feedback of gonadal hormones inhibits gonadotropin release.
Prolactin (PRL) promotes milk production in humans. Its secretion is prompted by prolactin-releasing hormone (PRH) and inhibited by prolactin-inhibiting hormone (PIH).
The neurohypophysis stores and releases two hypothalamic hormones:
Oxytocin stimulates powerful uterine contractions, which trigger labor and delivery of an infant, and milk ejection in nursing women. Its release is mediated reflexively by the hypothalamus and represents a positive feedback mechanism.
Antidiuretic hormone (ADH) stimulates the kidney tubules to reabsorb and conserve water, resulting in small volumes of highly concentrated urine and decreased plasma osmolality. ADH is released in response to high solute concentrations in the blood and inhibited by low solute concentrations in the blood. Hyposecretion results in diabetes insipidus.
Thyroid gland
Main article: Thyroid
The thyroid gland is located in the anterior throat. Thyroid follicles store colloid containing thyroglobulin, a glycoprotein from which thyroid hormone is derived.
Thyroid hormone (TH) includes thyroxine (T4) and triiodothyronine (T3), which increase the rate of cellular metabolism. Consequently, oxygen use and heat production rise.
Secretion of thyroid hormone, prompted by TSH, requires reuptake of the stored colloid by the follicle cells and splitting of the hormones from the colloid for release. Rising levels of thyroid hormone feed back to inhibit the pituitary and hypothalamus.
Most T4 is converted to T3 (the more active form) in the target tissues. These hormones act by turning on gene transcription and protein synthesis.
Graves' disease is the most common cause of hyperthyroidism; hyposecretion causes cretinism in infants and myxedema in adults.
Calcitonin, produced by the parafollicular cells of the thyroid gland in response to rising blood calcium levels, depresses blood calcium levels by inhibiting bone matrix resorption and enhancing calcium deposit in bone.
Parathyroid glands
Main article: Parathyroid gland
The parathyroid glands, located on the dorsal aspect of the thyroid gland, secrete parathyroid hormone (PTH), which causes an increase in blood calcium levels by targeting bone, the intestine, and the kidneys. PTH is the antagonist of calcitonin. PTH release is triggered by falling blood calcium levels and is inhibited by rising blood calcium levels.
Hyperparathyroidism results in hypercalcaemia and all its effects and in extreme bone wasting. Hypoparathyroidism leads to hypocalcaemia, evidenced by tetany and respiratory paralysis.
Pancreas
Main article: Pancreas
The pancreas, located in the abdomen close to the stomach, is both an exocrine and an endocrine gland. The endocrine portion (pancreatic islets) releases insulin and glucagon and smaller amounts of other hormones to the blood.
Glucagon, released by alpha () cells when blood levels of glucose are low, stimulates the liver to release glucose to the blood.
Insulin is released by beta () cells when blood levels of glucose (and amino acids) are rising. It increases the rate of glucose uptake and metabolism by most body cells. Hyposecretion of insulin results in diabetes mellitus; cardinal signs are polyuria, polydipsia, and polyphagia.
Gonads
Main article: Gonad
The ovaries of the female, located in the pelvic cavity, release two main hormones. Secretion of estrogens by the ovarian follicles begins at puberty under the influence of FSH. Estrogens stimulate maturation of the female reproductive system and development of the secondary sex characteristics. Progesterone is released in response to high blood levels of LH. It works with estrogens in establishing the menstrual cycle.
The testes of the male begin to produce testosterone at puberty in response to LH. Testosterone promotes maturation of the male reproductive organs, development of secondary sex characteristics, and production of sperm by the testes.
Pineal gland
Main article: Pineal gland
The pineal gland is located in the diencephalon. Its primary hormone is melatonin, which influences daily rhythms and may have an antigonadotropic effect in humans.
Other hormone-producing structures
Many body organs not normally considered endocrine organs contain isolated cell clusters that secrete hormones. Examples include the heart (atrial natriuretic peptide); gastrointestinal tract organs (gastrin, secretin, and others); the placenta (hormones of pregnancystrogen, progesterone, and others); the kidneys (erythropoietin and renin); skin (cholecalciferol); and adipose tissue (leptin and resistin).
Developmental aspects of the endocrine system
Endocrine glands derive from all three germ layers. Those derived from mesoderm produce steroidal hormones; the others produce the amino acidased hormones.
The natural decrease in function of the female ovaries during late middle age results in menopause. The efficiency of all endocrine glands seems to decrease gradually as aging occurs. This leads to a generalized increase in the incidence of diabetes mellitus and a lower metabolic rate.
References
^ Endocrinology: Tissue Histology. University of Nebraska at Omaha.
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Glands (Endocrine, Exocrine)
Classification
Mechanism
Merocrine Apocrine Holocrine
Shape
Tubular gland Alveolar gland
Secretion
Serous glands Mucous glands Serous demilune
Ducts
Interlobar duct Interlobular duct Intralobular duct (Striated duct, Intercalated duct) Acinus/Lobe
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Human anatomy, endocrine system: endocrine glands (TA A11, GA 11.1269)
Islets of pancreas
Alpha cell Beta cell Delta cell PP cell Epsilon cell
Hypothalamic/
pituitary axes
+parathyroid
Pituitary
Posterior pituitary
Pars nervosa Median eminence Infundibular stalk
Pituicyte Herring bodies
Anterior pituitary
Pars intermedia Pars tuberalis Pars distalis
Acidophils (Somatotropes, Lactotropes) Basophils (Corticotropes, Gonadotropes, Thyrotropes) Chromophobe
Thyroid axis
Thyroidgland
Thyroid isthmus Lobes of thyroid gland Pyramidal lobe of thyroid gland Zuckerkandl's tubercle
Parafollicular cell Thyroid epithelial cell
Parathyroidgland
Oxyphilcell Chiefcell
Adrenalaxis:
Adrenalgland
Cortex
Zonaglomerulosa Zonafasciculata Zonareticularis
Medulla
Chromaffin cells
Paraganglia
Organ of Zuckerkandl
Gonadal axis
Gonad: Testes Ovaries Corpusluteum
Pinealgland
Pinealocyte Corpora arenacea
endocrine navs: anat/physio/dev/hormones, noncongen/congen/neoplasia, symptoms+signs/eponymous, proc
Categories: Endocrine systemHidden categories: Articles needing additional references from January 2010 | All articles needing additional references
by: gaga
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