Facts About Ondansetron Hydrochloride

Facts About Ondansetron Hydrochloride

Facts About Ondansetron Hydrochloride

Ondansetron hydrochloride is known as the drug to prevent postoperative nausea and vomiting. There are special concerns that you should know before you administer or take this drug.

Ondansetron hydrochloride is classified as an antiemetic. It is available in tablet form. Ondansetron hydrochloride is a selective blocking agent of the 5-HT3 receptor antagonist which are present both centrally in the chemoreceptor trigger zone of the postrema area and peripherally on vagal nerve terminals.

Indications and Usage:

Ondansetron hydrochloride is used to prevent nausea as well as vomiting usually associated with cancer chemotherapy. It is best used by patients who are receiving single high-dose radiotherapy or total body irradiation. With Ondansetron hydrochloride or any other antiemetics, it is not advised to have routine prophylaxis if you do not expect to experience vomiting or nausea postoperatively. Keep in mind that Ondansetron hydrochloride should be used only if there is a need to avoid nausea or vomiting postoperatively.

Meanwhile, Ondansetron hydrochloride does not change the respiratory depressant effects resulting from the use of alfentanil. The same is true with the degree of the neuromuscular blockade that is produced by atracurium. The drug is also absorbed effectively from gastrointestinal tract. Studies showed that mean bioavailability of the drug in healthy subjects is about 56 percent.

Contraindications:

Ondansetron hydrochloride should not be taken by patients who are hypersensitive to the drug. There are indications that hypersensitivity reactions occurred in patients who showed hypersensitivity to other 5-HT3 receptor antagonists.

On the other hand, Ondansetron hydrochloride does not have the capability to stimulate intestinal or gastric peristalsis. The drug should not be a replacement to nasogastric suction. It should be noted that taking Ondansetron hydrochloride following chemotherapy-induced vomiting and nausea or abdominal surgery may hide a gastric distension or progressive ileus.

Adverse Reactions:

Some adverse events reported during clinical trials are:

Transient or temporary ECG changes

Hypersensitivity reactions such as angioedema, anaphylaxis, shortness of breath, laryngeal edema, stridor, bronchospasm, hypotension.

Shock, laryngospasm and cardiopulmonary arrest

Liver enzyme abnormalities

Hiccups

Oculogyric crisis

Urticaria

Eye disorders

In the event of an overdose of Ondansetron hydrochloride, patients should be treated with the right supportive therapy.

Read more about Ondansetron hydrochloride in the newly published Ondansetron hydrochloride Review for more information.

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