Glutathiones Functions And Usage

Reduced glutathione is a natural synthesis peptide in human cytoplasm

. It is composed of glutamic acid, cysteine, glycine and thiol. It is widely distributed in various organs within the body and has played an important role in maintaining cell biological functions. Reduced glutathione is the prosthetic group of glyceraldehyde phosphate dehydrogenase and the enzyme of glyoxal enzyme and triose dehydrogenase coenzyme. Astaxanthin involves in the in vivo TCA cycle and glucose metabolism.

Glutathione can activate a variety of enzymes, such as sulfhydryl enzymes. Thereby it contributes to the sugar, fat and protein metabolism and it can affect the metabolic processes of the cell. Combination of thiol free radicals can be converted into easy to metabolic the acids in order to accelerate the excretion of free radicals, help to reduce the toxic side effects of chemotherapy, radiotherapy, chemotherapy, radiation therapy had no significant effect, such as protection of the renal tubules from cisplatin damage to the main mechanism for renal tubular cells containing glutathione peptide detoxification amide GGT pain cell does not have this enzyme, it does not affect the cytotoxic effect of this product while protecting normal tissue but organs. More obvious and the treatment of radiation enteritis; anemia, poisoning, or inflammation caused by systemic or local hypoxemia in patients, can reduce tissue damage and promote repair.

By the reaction of methyl transfer and switch C amino, GSH can protect the liver synthesis, detoxification, inactivated hormone function, and the promotion of bile acid metabolism, gastrointestinal absorption of fat and fat-soluble vitamin. Platinum smooth ammonium chloride, cyclophosphamide, doxorubicin, red than adriamycin, bleomycin chemotherapy, especially high-dose chemotherapy. At the same time, its radiation therapy in patients with a variety of hypoxemia: such as acute anemia, adult respiratory distress syndrome, sepsis, etc., but also plays a significant role. Liver diseases: viral, drug toxicity, alcohol toxicity and liver damage caused by other chemicals toxic to the use of GSH. It can be used for the adjuvant treatment of organic phosphorus, amino or nitro compounds poisoning.

Dosage of reduced glutathione: intravenous: dissolve it in injection water and add l100 ml normal saline intravenous infusion of less than 20ml of normal saline with slow intravenous injection. In the biotin intramuscular administration: to be dissolved water for injection, intramuscular injection. In 15 minutes prior to chemotherapy drugs, 1.5g/m2 of GSH dissolved in 100 ml normal saline, intravenous infusion within 15 minutes, 2 to 5 days daily intramuscular injection of this product 600mg. In the use of cyclophosphamide for the prevention of urinary tract damage, it is recommended that intravenous injection product completed within 15 minutes immediately after the injection in CTX infusion use ammonium chloride platinum chemotherapy, the recommended dosage should not exceed 35mg/mgammonium chloride platinum, so as not to affect the effect of chemotherapy.

by: anelwew

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