Hsv And Cognitive Deficits
Cognitive functioning and serologic evidence of infection with potentially neurotropic
herpes viruses were measured in 117 individuals with bipolar disorder and in 100 individuals without a history of psychiatric disorder. Cognitive functioning was evaluated with the repeatable battery for the assessment of neuropsychological status.
For each patient, serologic evidence of infection was ascertained by the measurement of serum immunoglobulin G class antibodies with specificities for six potentially neurotropic human herpes viruses. The association between serologic evidence of herpes virus infection and cognitive functioning was analyzed by univariate analyses, as well as multivariate analyses that included demographic and clinical factors associated with cognitive functioning.
Serologic evidence of infection with herpes simplex virus type 1 was an independent predictor of decreased cognitive functioning in the individuals with bipolar disorder. Discriminant function analysis indicated that most of the difference in cognitive functioning between individuals who were antibody positive and antibody negative for herpes simplex virus type 1 could be attributed to immediate verbal memory.
There was no significant association between cognitive functioning and the other human herpes viruses. No association between antibodies to herpes viruses and cognitive functioning was found in the control individuals without a history of psychiatric disorder. Serologic evidence of herpes simplex virus type 1 infection is associated with cognitive impairment in individuals with bipolar disorder.
HSV infection also causes several distinct medical disorders. Common infection of the skin or mucosa may affect the face and mouth (orofacial herpes), genitalia (genital herpes), or hands (herpes whitlow). More serious disorders occur when the virus infects and damages the eye (herpes keratitis), or invades the central nervous system, damaging the brain (herpes encephalitis).
Patients with immature or suppressed immune systems, such as newborns, transplant recipients, or AIDS patients are prone to severe complications from HSV infections. HSV infection has also been associated with cognitive deficits of bipolar disorder, and Alzheimer's disease, although this is often dependent on the genetics of the infected person.
In all cases HSV is never removed from the body by the immune system. Following a primary infection, the virus enters the nerves at the site of primary infection, migrates to the cell body of the neuron, and becomes latent in the ganglion. As a result of primary infection, the body produces antibodies to the particular type of HSV involved, preventing a subsequent infection of that type at a different site.
In HSV-1 infected individuals, seroconversion after an oral infection will prevent additional HSV-1 infections such as whitlow, genital herpes, and keratitis. Prior HSV-1 seroconversion seems to reduce the symptoms of a later HSV-2 infection, although HSV-2 can still be contracted. Most indications are that an HSV-2 infection contracted prior to HSV-1 seroconversion will also immunize that person against HSV-1 infection.
There is currently no cure that can eradicate herpes virus from the body, but antiviral medications can reduce the frequency, duration, and severity of outbreaks. Certain dietary adjustments, dietary supplements, and alternative remedies are believed to be beneficial in the treatment of herpes, either alone, or in conjunction with prescribed antiviral therapy.
The herpes virus remains dormant in the ganglia, seemingly inactive, however once provoked/aggravated, the virus becomes symptomatic. It travels down the ganglia and forms blisters on the surface of the skin causing an outbreak, often reoccurring in the same location.
As the pathogenic factors are highly symptomatic and acute during an outbreak, a high intensity treatment should be used during this stage, whereas a gentler antiviral treatment should be used when the virus is dormant, to help act as suppressive therapy, which is why we developed HSVSuppressor-Rx.
HSVSuppressor-Rx is a softer antiviral treatment designed for daily application/suppressive therapy. It stays in the skin and system longer, has slower evaporation. Its antiviral nature helps block receptor sites of the herpes virus and assists immune function. HSVSuppressor-Rx is a prophylactic and can be applied daily. To learn more, please go to http://www.naturespharma.org.
by: bcured
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