Learning More About Pagets Disease

Fosamax has always been among the most widely used drugs in the United States over the years

. However, you can say that the drug and Merck, its manufacturer, also had their bad times when you look back and ahead at Fosamax lawsuits. This, and other drugs on the same classification are considered as the osteoporosis first line of treatment. Additionally, this drug is also prescribed to treat a less popular bone condition known as Pagets disease.

Pagets disease, also known to many as osteitis deformans, is the next most prevalent bone disease after osteoporosis in the United States. Moreover, this condition commonly occurs in people beyond 40 years old where the ratio from male to female is 1.2:1. Even if the disease can be present in various countries in the world, it occurs chiefly in European places such England, France and Germany.

Pagets disease is a localized and chronic disorder that can result in enlarged and misshapen bones. In the early stage of Pagets disease, the cycle of bone remodeling loses stability with bone resorption becoming more rapid as a result of the increasing number of bone cells responsible for breaking down the bones. It then proceeds to a stage with heightened bone formation causing bones that are larger but weaker than usual.

Pagets disease can have an effect on practically any bone in the skeleton but it commonly hits the long bones, spine, skull and the pelvis. Most of the time, people with continue to live without knowing that they have Pagets disease chiefly because this disease is often asymptomatic. Others may exhibit manifestations which depends on the afflicted bone of the disease.

When left untreated, this disease can lead to certain complications. For Instance, Pagets disease with skull involvement can ultimately lead to the following problems:

- Deafness

- Vertigo

- Tinnitus

- Dental malocclusion

- Basilar invagination

- Cranial nerve disorders

In most cases, people who are diagnosed with Pagets disease are treated with Fosamax or other bisphosphonates. However, there are findings suggesting that the use of Fosamax may put you at risk for serious problems including atypical fractures of the thigh bone. A significant number of people claiming to have been laid up by the long term effects of the drug are now determined to file a Fosamax lawsuit against Merck.

by: Ronald Redman

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