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During upper gastrointestinal endoscopy we studied in vivo duodenal mucosa in patients

with celiac disease using endocytoscopy, a novel diagnostic technique allowing in vivo real-time visualization of mucosa under x 450 magnification. Sixteen patients with documented celiac disease and seven controls without celiac disease were studied. Endocytoscopic images obtained from several fields were compared in a blinded fashion to standard histology. Endocytoscopy showed three different patterns of in vivo histology: christian louboutin (1) the presence of normal-appearing, long, thin villi, lined with clearly distinguishable surface epithelial cells, considered to be normal duodenal mucosa (n=15, all controls and eight celiac disease patients); (2) the presence of thick, shortened villi, reflecting partial villous atrophy (n=4); and (3) the total absence of villi and the presence of enlarged crypt orifices, reflecting total villous atrophy (n=4). Good concordance between endocytoscopy and standard histology was found in all 16 patients with celiac disease," wrote T. Matysiak-Budnik and colleagues, INSERM.

The researchers concluded: "Endocytoscopy allows in vivo, real-time, noninvasive visualization and characterization of villous architecture and may be a promising method for in vivo evaluation of duodenal mucosa in celiac disease." louboutin shoes

Matysiak-Budnik and colleagues published their study in Endoscopy (In vivo real-time imaging of human duodenal mucosal structures in celiac disease using endocytoscopy. Endoscopy, 2010;42(3):191-6). christian shoes

For additional information, contact T. Matysiak-Budnik, Institut des Maladies de l'Appareil Digestif - INSERM U913, CIC 04 et Service d'Hepato-Gastroenterologie, Hotel Dieu, CHU de Nantes, 44093 Nantes, France. christian louboutin shoes

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