Nystatin and triamcinolone acetonide
Nystatin and triamcinolone acetonide
Nystatin and triamcinolone acetonide
Nystatin and triamcinolone acetonide
Side/Adverse Effects
Note: Some, although not all, {10} formulations of the cream dosage form contain ethylenediamine, a potent sensitizer. Other sensitizers may also be present.
Side/adverse effects may be more pronounced with the use of an occlusive dressing; also, they may be more severe with fluorinated corticosteroids.
Since topically applied corticosteroids may be absorbed systemically, systemic effects may occur with prolonged use. The risk of adrenal suppression increases with the potency of the corticosteroids, the size of the area of application, and the duration of therapy. However, serious side/adverse effects with dermatological use are unlikely. {01} {02} {03} {04} {05}
The following side/adverse effects have been selected on the basis of their potential clinical significance (possible signs and symptoms in parentheses where appropriate)not necessarily inclusive:
Those indicating need for medical attention
Incidence rare {10} {16}
Hypersensitivity (blistering, burning, dryness, itching, peeling, or other sign of irritation not present before therapy){01}{02}{03}{04}{05}{25}
With prolonged use
Acne or oily skin
increased hair growth, especially on the face
increased loss of hair, especially on the scalp{01}{02}{03}{04}{05}{25}
reddish purple lines on arms, face, legs, trunk, or groin
skin atrophy (thinning of skin with easy bruising)
Nystatin and triamcinolone acetonide
Patient Consultation
As an aid to patient consultation, refer to Advice for the Patient, Nystatin and Triamcinolone (Topical).
In providing consultation, consider emphasizing the following selected information ( = major clinical significance):
Before using this medication
Conditions affecting use, especially:
Sensitivity to nystatin or corticosteroids
PregnancyTopical corticosteroids may be systemically absorbed; potent corticosteroids have been shown to be teratogenic in animals following topical application
Breast-feedingSystemic corticosteroids are distributed into breast-milk and may cause growth suppression in the infant; topical corticosteroids may be systemically absorbed
Use in childrenChildren may absorb a proportionately larger amount of topical corticosteroid than adults, making them more susceptible to HPA axis suppression and Cushing's syndrome
Other medical problems, especially Herpes simplex; tubercular infections of the skin; vaccinia, eczema vaccinatum, varicella, or other viral infections of the skin
Proper use of this medication
Not for ophthalmic use {16} {25}
Checking with physician before using medication on other skin problems
Applying a thin layer of medication to affected area and rubbing in gently and thoroughly
Not applying occlusive dressing over this medication unless directed to do so by physician; wearing loose-fitting clothing when using on inguinal area; avoiding tight-fitting diapers and plastic pants on diaper area of children {16} {25}
Compliance with full course of therapy; not using more often or longer than directed by physician; excessive use on thin skin areas may result in skin atrophy and stretch marks
Proper dosing
Missed dose: Applying as soon as possible; not applying if almost time for next dose
Proper storage
Precautions while using this medication
Using hygienic measures to cure infection or prevent reinfection; keeping affected area as cool and dry as possible {10}
Checking with physician if no improvement within 2 or 3 weeks {10}
May be more likely to cause systemic toxicity in children; chronic use may interfere with growth and development also; having children closely monitored by their physician
Diabetics: May rarely {10} cause hyperglycemia and glucosuria; checking with physician before changing diet or dosage of antidiabetic medication
Nystatin and triamcinolone acetonide
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