Preparation of anti-cancer drug research and development in Lanzhou will "poison" attack "poisonous" - cancer - th

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Preparation of anti-cancer drug research and development in Lanzhou will "poison" attack "poisonous" - cancer - th

A widely distributed in the grasslands of Gansu and other places of toxic plants?? Gansu Oxytropis, the main active ingredient is swainsonine grams of "cancer" winning "magic weapons": inhibit tumor cell growth and metastasis, activation of the human body immunity, drug side effects. Learned recently from the Chinese Academy of Sciences, Lanzhou compounds have learned from the northwest by the respective CAS Key Laboratory of Plant Resources in Chemistry?? Gansu Province Natural medicine Laboratory commitment to the "Preparation of swainsonine key technology development" project, recently passed the provincial appraisal results. It makes use of the birth of the rich resources of Gansu Oxytropis, low toxicity and high research and development, mechanism and biological targets for specific anti-cancer drugs possible.

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News Background Oxytropis is Gansu Gansu, Qinghai grasslands major poisonous plant distribution, has long been seriously affected the development of animal husbandry and the environment. However, the main active ingredient of swainsonine on the tumor growth and metastasis inhibition, the role of immune activation has obvious effects on the human treatment of malignancies. It can stimulate strong immune organisms, and promote value-added within the bone marrow, so that chemotherapy does not cause bone marrow suppression and ensuing neutropenia leukopenia occurred. Studies have shown that swainsonine and other Anti-cancer drugs Agent than to kill cancer cells in the same time, the human immune system has a protective effect, minimal side effects is also rare and endangered than Medicine Taxol from the broader alternatives.

It is understood that the present domestic and foreign species extracted from the spine, separation technology swainsonine basically stay in the laboratory level, due to the complexity of these technical procedures, high cost, can not be transferred to the industrialization. Therefore, isolated from plants swainsonine has been the problems plaguing one of industrialization, but also a fundamental limitation of the order of swainsonine as a component of drug development. Natural Medicine of Gansu Province Key Laboratory of researchers over the years, screening and the establishment of a "cycle solvent extraction? Macroporous resin impurity? Ion exchange resin enrichment? Second counter-current chromatography purification" as the core technology of industrialization swainsonine preparation, experiment and effective composition in more than 80%, the content up to 90%. If this is the basic research and development Traditional Chinese medicine Drugs, each 1 kilogram of swainsonine, profit worth 36 million yuan, annual output of the production line, if built, the output value is expected to more than 4,000 million yuan, profit more than 2680 million, has great economic benefits, the market prospect is broad.

To natural medicine as a resource for anti-cancer drugs, anti-cancer drug research at home and abroad has become the most promising directions. At present, although the Chinese government attaches great importance to the antitumor drugs, but have not yet developed with independent intellectual property rights of anti-tumor drug innovation. Lanzhou compounds prepared by swainsonine developed technology is expected to have independent intellectual property rights, high efficacy, selectivity, low toxicity anti-tumor new drug, thus occupying the international control of anticancer drug market, has important Medicine Strategic value.

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