Research Progress Of Retinoic Acid Binding Protein
Retinoic acid is an important signal molecular and associate with the cell proliferation
, differentiation, and apoptosis, which activate the nuclear receptors, retinoic acid receptor (RAR), in turn, regulate transcription and expression of multiple target genes in vivo. In tumor treatment, retinoic acid plays an important role, it inhibit the development and progression of the carcinoma cell and is a good drug in tumor-inhibition. But, the biological role of the retinoic acid mainly depends on the cellular retinoic acid-binding protein.
Intracellular retinoic acid binding protein first discovered in the organization in the mouse, and chicken embryo metatarsal skin, its function is considered to be a protection against oxidation of tretinoin soluble. It helps transporter, as well as assists the function of retinoic acid degradation. In vertebrates, the intracellular retinoic acid binding protein to the existence of two subtypes in invertebrates, only one subtype. Retinoic acid binding protein is a class of small molecular weight proteins, they are highly conserved in vertebrates, and the homology of about 75%.
Retinoic acid binding protein plays an important part of the biological functions of retinoic acid, retinoic acid is a metabolite of vitamin A in the body. Retinoic acid, including the various isomers, which are a class of small hydrophobic molecules, is widely distributed in the cells, the extracellular environment, its physiological function mainly by two types of protein-mediated retinoic acid binding protein and retinoic acid by body, the retinoid X receptor. Is generally believed that retinoic acid binding protein is responsible for retinoic acid in the cytoplasm, to be sent to the retinoic acid receptors within the nucleus, in order to start with a retinoic acid response element gene transcription; or retinoic acid binding protein through a combination of cytoplasmic of retinoic acid in regulating retinoic acid metabolism.
Retinoic acid has many important physiological functions in vivo, as with other steroid hormones, the body a certain concentration of retinoic acid can regulate cell proliferation, differentiation, mature, is essential for normal body growth and development and various physiological activities. More importantly, by scholars attached great importance to retinoic acid in the tumor and the treatment of retinoic acid can induce leukemia cell line or primary cultured acute promyelocytic leukemia cell differentiation to mature.
Retinoic acid binding protein is a lipid-binding protein superfamily, and lipid-binding protein is a class of intracellular, extracellular low molecular weight proteins, combined with a variety of hydrophobic ligands, each member has a tissue-specific. The lipid-binding proteins include fatty acid binding protein, P2, phospholipid protein and fat cells LBP.
Alcohols, retinol binding protein is a principal member of intracellular lipid-binding protein, they are combined and transit in a variety of active metabolite of vitamin A in the body, including intracellular retinol-binding protein, intracellular, as retinoic acid binding protein, cell within the retinal binding protein binding protein and light receptors, retinoic alcohols five categories. Them space structure is highly conserved, widely distributed, versatile, and close to the development of many diseases. In vertebrates, the intracellular retinoic acid binding protein is divided into and two subtypes. There is only one in invertebrates.
Cosmetic raw material retinoic acid is an important signaling molecule to participate in a variety of cellular processes. It regulates a variety of gene expression. Retinoic acid signaling system includes retinoic acid, intracellular retinoic acid binding protein, retinoic acid nuclear receptor, receptor dimer and retinoic acid response element. Retinoic acid regulates signaling system and ultimately activates or inhibits the corresponding functional expression of target genes. But the system itself is also subject to multi-level feedback regulation. It has been shown that retinoic acid can regulate the transcriptional expression of many genes, such as extracellular matrix layered protein subunit, epidermal growth factor receptor, protein kinase C, human osteocalcin protein and transmembrane protein tyrosine kinase receptor. Even retinol-binding protein is also bounded by its adjustment.
Source:http://www.cosprm.com
by: anelwew
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