Vision Shopsters: Alzheimers Disease: Drug Treatment Strategies 2010
Vision Shopsters: Alzheimers Disease: Drug Treatment Strategies 2010
This report presents the findings of a comprehensive survey of current clinical practices in the treatment of Alzheimer's Disease (AD). This was carried out following the participation of more than 220 physicians, practicing predominantly in the US. The purpose of this study was to establish current everyday drug treatment practices for AD and how current drug classes, individually and in combination, are prescribed for mild, moderate and severe stages of the disease. As part of this survey, more than 200 physicians also reported on the principal challenges of treating this disease and these findings are presented, analysed and discussed in this report.
The treatment of AD remains an area of significant unmet need, with therapies based largely on two drug classes: the cholinesterase inhibitors and the NMDA receptor antagonists. These drugs target the symptoms of the disease, however there is considerable need for disease-modifying therapies. Other therapeutic agents are used to treat this disease, which have also been surveyed as part of this work. This survey investigated the use of these drug classes for the treatment of mild, moderate and severe AD, as well as examining the use of drug combinations. While available drugs to treat AD are limited, current practices in how they are used and combined in treating mild, moderate and severe disease, vary greatly. This survey has examined current treatment practices, which includes off-label use.
In a therapeutic field where treatments for AD are very limited, physicians seek to extent their understanding in this area in an effort to better understand how current drugs and combinations can best be used to target mild, moderate and severe stages. Knowledge in these areas is also important to drug developers, who seek a better understanding of patient needs and outcomes as part of their own efforts to develop more effective therapies. The present survey was carried out to meet interest in these areas. This report presents an analysis of the survey findings and includes:
1. Clinics: comprehensive details of current treatments for AD, provided by more than 220 clinics.
2. Markets and opportunities: in-depth information and analysis relevant to therapeutic markets and opportunities in the AD field.
3. Physicians: of the participants, 92% practiced in the US, 2% practiced in Canada and 6% in other countries. Of these, 28% worked in a geriatric department, 20% practiced in a hospital general department, 15% worked in a general practice and 10% worked in a university research/clinical practice. Approximately 90% of the participants worked as Geriatricians and 5% were General Physicians.
4. Disease stages: estimates of the percentage (%) of AD patients treated by study participants for mild, moderate or severe disease.
5) Mild AD: estimates of the percentage (%) of mild AD patients who are prescribed Cholinesterase Inhibitors (e.g. donepezil, Aricept; rivastigmine, Exelon; galantamine, Reminyl; NMDA Receptor Antagonist (e.g. memantine - Namenda, Axura, Ebixa; Nootropics (e.g. piracetam - Nootropil); and other drug classes.
6) Mild AD: first choice and second choice drug combinations of two or more of the drug classes Cholinesterase Inhibitors; NMDA Receptor Antagonist; Nootropics; Colostrinin; Vitamins and other drugs for the treatment of mild disease.
7) Moderate AD: estimates of the percentage (%) of moderate Alzheimer's disease patients who are prescribed Cholinesterase Inhibitors (e.g. donepezil, Aricept; rivastigmine, Exelon; galantamine, Reminyl; NMDA Receptor Antagonist (e.g. memantine - Namenda, Axura, Ebixa; Nootropics (e.g. piracetam - Nootropil); and other drug classes.
8) Moderate AD: first and second-choice drug combinations of two or more of the drug classes Cholinesterase Inhibitors; NMDA Receptor Antagonist; Nootropics; Colostrinin; Vitamins and other drugs for the treatment of moderate disease.
9) Severe AD: estimates of the percentage (%) of severe AD patients who are prescribed Cholinesterase Inhibitors (e.g. donepezil, Aricept; rivastigmine, Exelon; galantamine, Reminyl; NMDA Receptor Antagonist (e.g. memantine - Namenda, Axura, Ebixa; Nootropics (e.g. piracetam - Nootropil); and other drug classes.
10) Severe AD: first and second-choice drug combinations of two or more of the drug classes Cholinesterase Inhibitors; NMDA Receptor Antagonist; Nootropics; Colostrinin; Vitamins and other drugs for the treatment of severe disease.
11) The principal challenges and issues encountered in the treatment of Alzheimer's disease.
Background to Alzheimer's disease
A prevalence study in 2005 estimated there were 243 million people suffering from dementia globally, with 46 million new cases added every year. In the absence of a cure, the study suggested dementia sufferers will double every 20 years to 811 million by 2040. Of those reported to be suffering from dementia, 60% were living in developing countries, a figure expected to rise to 70% by 2040. Rates of increase of dementia are not uniform, and between 2001 and 2040 were projected to increase by 100% in developed countries and by more than 300% in India, China, and their south Asian and western Pacific neighbours. More than 50% of these dementia cases are due to AD.
Today, approximately five million Americans suffer from AD, a figure expected to rise to 14 million by 2050 if a cure is not found. One in eight persons in the US over the age of 65 and nearly half of those over 85 have AD. Direct and indirect costs of AD and other dementias in the US amount to more than $148 billion annually. It is estimated that 10 million Americans are caring for a person with AD or another dementia, one third of whom are over the age of 60. It is estimated the worldwide costs for dementia care are over $315 billion annually.
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