Vitamin D biomarker research finds links to heart failure-related deaths

Researchers in the US say they have discovered a link between adults found to have

a low level of a vitamin D biomarker and significant increase in the risk of premature death and death from heart failure.

According to Cardiology Today, scientists looked at results from a sample group involved in the National Health and Nutrition Examination Survey which ran between 1988 and 1994, and was followed for mortality until 2000. They were looking to examine the possible links between a low concentration of serum 25-hydroxyvitamin D, also known as 25(OH)D, and an increased risk of premature death and heart failure.

Once results were adjusted to factor in other things such as age and sex, it was found that those people involved in the study who had a deficiency of vitamin D were 3.4 times more at risk of death from heart failure than people with a normal level of 25(OH)D. The study concluded that adults with low serum 25(OH)D levels face a significantly higher risk of death from heart failure and premature death.

The research, which was presented in September at the Heart Failure Society of America's 14th annual scientific sessions event, is another example of biomarkers being used to help research and development efforts. Whether they are being used by research teams to help develop diagnostic tests, as part of drug development research or during clinical trials, there is little doubt that biomarkers are playing an important role in the medical world. From large laboratories to small operations, companies all over the country and indeed the world are finding that biomarkers are helping them to make important advances and gain a better understanding of the human body.

Genetic researcher Sreeram Ramagopalan and a team at Oxford University have been carrying out work relating to vitamin D. They believe that the current RDI, or recommended daily intake, is too low at 200 IU (International Units) for people younger than 51, 400 IU for those aged between 51 and 70 and 500 IU for people over 70. According to WebMD, Ramagopalan believes along with other experts that 2,000 IU may be the optimal daily amount for people looking to prevent disease.

The tests carried out in America and the UK show just how important it is that biomarker research remains a key priority within laboratories around the world, allowing people everywhere to benefit from advances in our knowledge of biomarkers.

Vitamin D biomarker research finds links to heart failure-related deaths

By: Ben Dafftie

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