Most of your body's internal organs are covered by a membrane called the mesothelium. When a person gets a type of malignant or benign cancer called mesothelioma it affects the mesothelium.The pleura is the lining around your lungs. Most mesothelioma cases start in the pleura or the peritoneum, which is the lining that surrounds your abdomen.What Causes Mesothelioma?Wherever it begins, the disease was almost always a result of being exposed to...more
Pleural mesothelioma is a type of cancer that develops in the lung's outer linings - the pleura.Your mesothelium is a large covering of tissue that protects a number of your body's organs in both your abdominal cavity and your chest cavity. Your pleura is the two-layered membrane surrounding your lungs.The inner layer of the pleura surrounds your lungs. The outer layer connects to the wall of your chest. The small space between the two is the...more
Another interesting study is called, Preoperative Tumor Volume Is Associated With Outcome In Malignant Pleural Mesothelioma by Harvey I. Pass, MD, Barbara K. Temeck, MD, Karen Kranda, RN, Seth M. Steinberg, PhD, Irwin R. Feuerstein, MD - From the Thoracic Oncology Section,a Biostatistics and Data Management Section,b National Cancer Institute, Diagnostic Radiology Department,c Warren Magnusen Clinical Center, National Institutes of Health, Bethesda, Md. GENERAL THORACIC SURGERY - J Thorac Cardiovasc Surg 1998;115:310-318. Here is an excerpt: Objectives: Our objective was to analyze the impact of preoperative and postresection solid tumor volumes on outcomes in 47 of 48 consecutive patients undergoing resection for malignant pleural mesothelioma who were treated prospectively and randomized to photodynamic therapy or no photodynamic therapy. Methods: From July 1993 to June 1996, 48 patients with malignant pleural mesothelioma had cytoreductive debulking to 5 mm or less residual tumor by extrapleural pneumonectomy (n = 25) or leurectomy/decortication (n = 23). Three-dimensional computed tomographic reconstructions of preresection and postresection solid tumor were prospectively...more
Another interesting study is called, Pleurectomy for mesothelioma. By Brancatisano RP, Joseph MG, McCaughan BC - Department of Surgery, Repatriation General Hospital Concord, NSW. Med J Aust. 1991 Apr 1;154(7):455-7, 460. Here is an excerpt: Abstract - OBJECTIVE: To assess the effectiveness and safety of parietal pleurectomy in establishing a...more
Another interesting study is called, Value of the Ber-EP4 antibody in differentiating epithelial pleural mesothelioma from adenocarcinoma : The M.D. Anderson experience and a critical review of the literature - American Society of Clinical Pathologists, Chicago, IL, ETATS-UNIS (1931) (Revue) by ORDONEZ N. G. (1) ; 1998, vol. 109, no1, pp. 85-89...more
Another interesting study is called, Genetic alteration of the -catenin gene (CTNNB1) in human lung cancer and malignant mesothelioma and identification of a new 3 p 21.3 homozygous deletion Oncogene 2001, vol. 20, no31, pp. 4249-4257 by Shigemitsu Kikuo; Sekido Yoshitaka ; Usami Noriyasu; Mori Shoichi; Sato Mitsuo; Horio Yoshitsugu; Hasegawa Yoshinori; Bader Scott A.; Gazdar Adi F. ; Minna John D.; Hida Toyoaki; Yoshioka Hiromu; Imaizumi Munehisa; Ueda Yuichi; Takahashi Masahide; Shimokata Kaoru Here is an excerpt: Abstract - The -catenin gene (CTNNB1) has been shown to be genetically mutated in various human malignancies. To determine whether the -catenin gene is responsible for oncogenesis in thoracic malignancies, we searched for the mutation in 166 lung cancers (90 primary tumors and 76 cell lines), one blastoma and 10 malignant mesotheliomas (two primary tumors and eight cell lines). Among the lung cancers, including 43 small cell lung cancers (SCLCs) and 123 non-small cell lung cancers (NSCLCs), we identified four alterations in exon 3, which is the target region of mutation for stabilizing -catenin. One primary adenocarcinoma had a somatic mutation from C to G, leading to...more
An interesting study is called, Dickkopf-1 antagonizes Wnt signaling independent of -catenin in human Mesothelioma - Biochemical and Biophysical Research Communications - Volume 323, Issue 4, 29 October 2004, Pages 1246-1250 by Amie Y. Lee, Biao He,...more
Another interesting study is called, Lymph Node Metastasis: as the Initial Manifestation of: Malignant Mesothelioma: Report of Six Cases by Sussman, Jeffrey M.D.; Rosai, Juan M.D. Here is an excerpt: Abstract - We present six cases in which...more
An interesting study is called, Early Response Evaluation in Malignant Pleural Mesothelioma by Positron Emission Tomography With [18F] Fluorodeoxyglucose by Giovanni L. Ceresoli, Arturo Chiti, Paolo A. Zucali, Marcello Rodari, Romano F. Lutman,...more
Another interesting study is called, The Human Type 2 Iodothyronine Deiodinase Is a Selenoprotein Highly Expressed in a Mesothelioma Cell Line by Cyntia Curcio, Munira M. A. Baqui, Domenico Salvatore, Bertrand H. Rihn, Steve Mohr, John W. Harney, P....more
Another interesting study is called, Value of thrombomodulin immunostaining in the diagnosis of Mesothelioma by N.G. ORDEZ Histopathology Volume 31, Issue 1, pages 2530, July 1997. Here is an excerpt: Aims: Even with the benefit of...more
Mesothelioma may cause from any kind of exposure to dust for prolong time, may be for years. Such kind of prolong exposure to dust particle usually happens in asbestos industries. So, it is common for the worker to get affected in...more