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Table of Contents : 1. Overview 81.1 Statement of Report 81.2 Objectives of this Report 81.3 Scope of the Study 91.4 Methodology 101.5 Executive Summary 112. Introduction 172.1 Pharmacogenomic Testing Overview 172.1.1 Clinical Applications 182.1.2 Technologies for Pharmacogenomic Diagnostic Tools 192.1.3 Drug and Diagnostic Combinations 222.1.4...more
Table of Contents : 1. Overview 131.1 Statement of Report 131.2 About This Report 131.3 Scope of the Report 131.4 Objectives 131.5 Methodology 151.6 Executive Summary 162. Introduction: Companion Diagnostics in Drug Development 192.1 Companion Diagnostics as Biomarkers 202.1.1 Potential Benefits of Biomarkers as Companion Diagnostics 222.2 Biomarkers in Different Phases of Drug Development 222.2.1 Drug Discovery and Development Process 222.2.2 Biomarkers in Drug Development 242.3 Drug Targets 242.3.1 Target Discovery Using Functional Genomics 262.3.2 Functional Genomics 262.3.3 Target Validation 282.3.3.1 Target Discovery 282.3.3.2 Lead Identification 282.3.4 Target and Biomarker Discovery 292.3.4.1 Biomarker Validation 292.4 Biomarkers in Drug Discovery, Development and Clinical Diagnostics 292.4.1 Role of Biomarkers in Drug Discovery, Preclinical, Clinical Development and Diagnostics 292.4.2 The Pipeline Problem 312.4.3 Biomarkers in the Drug Discovery Process 322.4.4 Segmentation of Biomarker Usage 322.4.5 Efficacy of Biomarkers as Surrogate Endpoints 332.4.6 Biomarkers Used to Reduce the Cost of Drug Development 342.4.7 Biomarkers: Challenges and Opportunities 342.4.8...more
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