China's New Drug R & D Capability To Improve I Class Medicine Developed By Leaf - New Drugs,

Recent years, new drug R & D capability has increased

, but compared with developed Western countries, in general, still at low level. More than 6,000 pharmaceutical enterprises nationwide, 98% of all production of generic drugs. The foreign pharmaceutical companies with only a small number of "blockbuster" level drugs, alone accounts for half of China's pharmaceutical market.

In the face of grim reality, more and more Chinese pharmaceutical companies recognize the importance of new drugs with independent intellectual property value. So how can Chinese pharmaceutical companies to catch up in international competition? "According to Yeh," The birth process for innovative drugs in China has provided valuable inspiration.

Like depression in the stretch of innovative drug development on high ground, suddenly grow a tree between the ground-breaking, to the pessimistic people from green to rekindle hope.

2008 3 3, "according to Ye" (enalapril folic acid tablets) was issued by the State Food and Drug Administration new drug class certificate, or innovative drug research and development will become a landmark event in the history. Experts pointed out that "according to Ye," the birth, not only on behalf of the individual compound drugs and medical direction for the future of drug development, but also to explore a path for innovative new drugs situation, but to reform our medical innovation provides an important inspiration.

New drug R & D chief scientist Professor Xu Xiping, said: "Before I give a small village who opened a small prescription, I was open to the whole world to a large prescription"

"According to Ye," the "big prescription" not come easily. As early as 1993, when the Anhui Medical University, Xi-Ping Xu Cooperation Chronic diseases in rural areas in Anhui Province to carry out epidemiological studies, he found that most heart patients with cerebrovascular disease accompanied by high HCY (homocysteine, the medical profession that led to a cardio-cerebral vascular diseases in vivo metabolites). Further epidemiological studies have shown that high HCY and ischemic heart disease, stroke (stroke) are related, but a closer relationship with the stroke. HCY and high blood pressure exist, synergy occurs through an influence HCY metabolism genes, so that the incidence of cardiovascular disease increased significantly. Xi-Ping Xu accordingly concluded, HCY, a causal relationship between hypertension and stroke rather than a simple association.

Another fact is that the United States, the Chinese stroke, possibly with a greater percentage of Chinese population the high HCY. If drugs can reduce blood pressure, and HCY, can prevent the incidence of stroke, which is high as a great power stroke patients up to 700 million of China, was particularly significant.

Result, "according to Ye (enalapril folic acid)," the idea of gradually clear. Subsequently, a series of innovative research results encouraging: confirmation of folic acid to reduce stroke by reducing the risk of HCY effect, confirmed by leaf for high HCY, multiple risk factors for stroke and high blood pressure control was better than single-use blood pressure medicine, clear treatment effect, form a "gene diagnostic reagents according to Ye +" and "individualized medicine" portfolio.

Smooth progress of research and development work: in 2000, carried out "according to Ye," pre-clinical studies. In 2005, six major cities across the country to carry out clinical trials. Since 2006, the core of the international authority of the results of paper after another medical journal "Lancet", "New England Journal of Medicine" and published in the international medical community response triggered. In 2008, after access to new drug certificate IV clinical study to assess, "according to Ye," commonly used antihypertensive drugs than the proportion of cardiovascular disease.

President of the International Union of hypertension that Professor Liu Lisheng, China's 200 million hypertensive patients, even if half of the patients taking "by leaves", in the cost of treatment remains unchanged, the annual reduction of several hundred thousand new cases of stroke.

The establishment of a new drug innovation system, and create a new drug innovation platform for developing innovative medicines found out by chance and random

To Xi-Ping Xu's dreams into reality, not just "according to Ye," the "big prescription", more significantly, he led the team after 15 years of research and development process for innovative drug research and development in China to explore a suitable conditions of a new road.

by: gaga

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