Globulins Of The Human Blood

In the human biochemistry study, the blood components are widely divided

. Human plasma being one of the important constituent is majorly responsible for the accurate flow of blood in the human body. Human plasma is made up of water and proteins and occupies almost 55% of total blood volume in the human body. However this substance is a regenerating substance in the body which can be easily formed again by it, so can be donated for medication or research purposes without causing any deficiency to the body.

In the human plasma there are 3 types of serum proteins present albumin, fibrinogen and Globulin. When the fibrinogen is separated from the plasma it becomes the serum part. Fibrinogen is the clotting part of the blood. Albumin is also a globular protein, but not a globulin. All other serum globular proteins except the albumin are globulins. Some globulins are produced in the liver, while others are produced by the immune system of the human body.

The serum globulins are categorized into 4 types based on its properties. Protein electrophoresis is the method which is used to categorize these serum globulins into the following four categories:

Alpha 1 globulins

Alpha 2 globulins

Beta globulins

Gamma globulins

Alpha globulins are a group of the globular proteins that are very volatile in an electrically charged solution or the alkaline solutions. These alpha globulins withhold several blood enzymes in it. There are various types of alpha globulins which are further divided into Alpha 1 and Alpha 2.

Beta globulins are also same like the Alpha globulins but are less volatile when compared to them. This is a globulin in blood plasma that carries iron and are transport proteins, serving as a substrates upon which other substances are formed, and perform other diverse functions in the human body.

Gamma globulins are the type of globulins that are identified by their position after the process electrophoresis is done for the extraction of serum protein. These are the antibodies which are very crucial in the development of various medications and therapeutic use. Being the heaviest, they are the slowest to segregate in Electrophoresis. Since they are immunologically active, they are also called as Immunoglobulin. These are very important part of human blood as their excess and deficiency both are not good for health and can cause a disease called "gammopathy". An excess of it is called as hypergammaglobulinemia whereas deficiency is called as hypogammaglobulinemia.

Injections are given to the patients to boost immunity in patients who are unable to produce the required gamma globulins quantity naturally because of an immune deficiency. Such injections are less common in modern medical practice than they were previously, as they have been replaced by the use of hepatitis A vaccine. However, being a substance taken from blood, gamma globulin injections, along with blood transfusions and intravenous drug use, could pass along Hepatitis C to its recipient, which is the major cause of its replacement in the medical use. Apart from gamma globulins, there are medications available foe alpha and bets too in the world which can be taken.

Learn more about such Biological products by visiting at http://www.accessbiologicals.com/

by: Michael Crowley

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