Those of you out there who don't have the time, or desire to lose weight by getting a daily dose of exercise are in luck: The simple fact of the matter is that you can lose weight without exercise. While you can't really make your heart and cardiovascular system stronger without getting your blood pumping via cardiovascular conditioning, losing weight is simply a matter of burning more calories than you're taking in per day.
This means that you either need to reduce your calories, or take fat-burning supplements to achieve your weight loss goals. Caloric requirements will vary significantly from person to person and are also gender specific. Men tend to burn more calories due to the simple fact that they have more muscle mass than women do. This means a man under 200 pounds can lose weight by sticking to a diet of 1800 - 2000 calories per day. A woman that weighs under 150 pounds should stick to a diet of around 1200 - 1500 per day, for maximum benefit.
It's all about what you eat...
Fiber is one of your greatest allies in the battle to lose weight without exercise. Excess carbohydrates will bond to fiber in your digestive system: Meaning they will pass through your bowels without being burned or stored as fat. Eating foods that are high in fiber, or better yet, taking a high quality weight loss supplement, with fiber added will make you easily lose weight without exercise. Eating a diet that's low in fat, relatively high in protein and with a minimum amount of carbohydrates (less than 200 grams per day) will usually do the trick.
Supplementation
Finding a weight loss supplement in this day and age is no great challenge. If you want to accelerate your weight loss, find a daily supplement that's high in fiber and helps boost your metabolism. Make sure to do your research first though: Some supplements will boost your heart rate along with your metabolism -- Stick to supplements that have a 100% natural rating on the label.