Keratin and science

Keratin and science

Keratin and science

Keratin is a highly durable protein that provides structure to several types of living tissues. It is a major component of mammalian hair and hooves, mammalian and reptilian nails and horns, reptile and fish scales, bird feathers, bird beaks, and the outermost layer of skin in most animals. Keratin provides a tough, fibrous matrix to these tissues. An important quality of keratin is its ability to flex in multiple directions without tearing.

Keratin's microscopic structure is the key to its durability and flexibility. The molecules of this protein twist into coils called alpha helices and contain many disulfide bonds (bonds between pairs of sulfur ions). Disulphide bonds are particularly stable and can resist the action of proteolytic enzymes, which specialize in breaking apart proteins. Keratin is also insoluble in water. Whenhuman hair is straightened or curled in a beautysalon, special chemicals must be used to break the disulfide bonds. The breaking and subsequent reconfiguration of these bonds allows the hair to change shape. The final shape depends on the relative positions of the sulfur ions in the new bonds.

The protective structures containing keratin form through a process called keratinization. In keratinization, precursor cells to the specific tissue types first migrate from the germinal layer to their target location. Then fibers of keratin gradually invade the precursor cells, displacing cellorganelles such as the nucleus andmitochondria . These organelles areresorbed and are not present in the mature tissue type. The differentiated, mature keratinized tissue is nonliving and incapable of sensory perception. Keratinized structures grow through the additional migration of differentiatinggerm cells , not through the division of the existing tissue cells.

Keratinized tissues can form onto a base of skin or bone. Keratinized structures such as hairs and fingernails are embedded in the skin. Calluses on hands or feet are mounds of keratin which have been created in response to repeated stress on a particular region of skin. Other structures, such as the horns of a bull, are rooted onto a bony core.

Keratinized structures take on a wide range of characteristics depending on the thickness of the protein layers. Hair is thin and flexible, whereas scales are often tough and inpenetrable. Keratin is also present in sharp structures such as spines and porcupine quills.

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