Lysozyme And Its Application In Animal Feed - Aquaculture Industry - China Turbo Thrust Bearing

Lysozyme derived from animals, plants and microorganisms

, can also be mass-produced through genetic engineering of lysozyme. Chemical stability of lysozyme is a more heat-resistant alkaline protein; the hydrolysis of fungal cell wall in cells and N-acetyl glucosamine and N-acetyl muramic acid between the -1, 4 glycoside bond, has antibacterial anti-inflammatory, anti-virus, enhance immunity and other effects. Be used to feed a antiseptic and sterilization, control sub-pig diarrhea, gastroenteritis and indigestion and other combat role in animal feed has broad application prospects.

On Lysozyme was first published in 1907, Bacillus subtilis from the report of the beginning of dissolution factor; two years later, the researchers pointed out that the egg a strong inhibition of enzyme function results; in 1922 the British bacteriologist Fleming was found in saliva, tears there is a distinct element of bacterial cell wall dissolved, its role has bacteriolytic lysozyme their name. With the deepening of research and found that not only dissolve the bacterial cell wall of lysozyme, as well as the role of lysozyme in the fungal cell wall, while its mechanism of action has also been further research. Lysozyme as a livestock feed additive application just begun, domestic livestock and poultry production have been reported in application of lysozyme, and achieved a better breeding results.

Chemical properties of lysozyme Lysozyme is a wide variety of plants and animals found in the body of the glycoside hydrolase, used in N-acetyl glucosamine and N-acetyl muramic acid between the -1, 4 glycosidic bonds, can be decomposed in a in the mucopolysaccharide cell wall of these bacteria. Egg white lysozyme is one of the most clear lysozyme, it is a 129 amino acid residues of the basic globular protein, the molecule sulfur in the four pairs of amino acid residues 4 SS bond formed between the isoelectric point In the pH value is about 10.8, a molecular weight of 14000. Its chemical properties are very stable, when the pH value of 1.2 ~ 11.3 in the context of dramatic changes, its structure is almost unchanged. In the acidic environment of the thermal stability of lysozyme strong, pH values from 4 to 7 heated at 100 for 45 minutes. Dry conditions can be long-term storage at room temperature, the pure white or slightly yellow crystals or amorphous powder, odorless, sweet, soluble in water, insoluble in acetone, ether. In 1965 researchers used X-ray crystal structure analysis to clarify the three-dimensional structure of lysozyme, lysozyme molecules near the Oval, size 4.5nm 3.0nm 3.0nm, the complexity of its conformation, only 25% of the spiral, the molecular Some regions have extended the fold structure. Research shows that almost all lysozyme non-polar within amino acid residues, hydrophobic interaction used in the folding of lysozyme conformation play an important role, the molecular surface of a deep crack, the size just to dissolve Na polysaccharide substrate 6 monosaccharide, which is the active site of lysozyme. In the lysozyme active site of glutamate by a third 15 and fifth 12 of the aspartic acid residues constitute the active site of the hydrolysis of microbial cell wall N-acetyl glucosamine and N-acetyl-cell wall acid between the -1, 4 glycosidic bond.

The biological function of lysozyme Bacterial cell wall by the quality of cell wall composition, cell wall quality by N-acetyl glucosamine, and N-acetyl muramic acid polymer consisting of alternating, cell wall acid residues can be connected peptide, called peptide polysaccharide. Peptidoglycan is the main component of bacterial cell wall, which is N-acetyl glucosamine, N-acetyl cell wall acid and peptide "tail" (usually four amino acid residues) form, N-acetyl glucosamine and N - acetyl muramic acid by -1, 4 glycosidic bond connecting peptide "tail" is a carboxylic acid via D-milk with glucose in N-acetyl-third carbon atom, the peptide through the peptide between the end of " Bridge "(the peptide bond or a few amino acid residues) phase, N-acetyl glucosamine, N-acetyl muramic acid, peptide" tail "and" peptide "bridge together to form multi-layered peptidoglycan mesh structure, as the cell wall skeleton, the structure of any bond breaking are instantly lead to bacterial cell wall damage. For G + bacteria and G-bacteria, the cell wall peptidoglycan content in different, G + bacterial cell wall composed almost entirely of peptidoglycan, while the G-bacteria only wall peptidoglycan layer.

Lysozyme effective bacterial cell wall peptidoglycan hydrolysis, its action site is N-acetyl glucosamine of a carbon atom and N-acetyl muramic acid of four carbon atoms of -1, 4 glycosidic bond, resulting in bacterial cell walls to become loose, lose the protective effect on cells, and finally to dissolve bacterial cell death.

by: gaga

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