Welcome to YLOAN.COM
yloan.com » Electronics » Maximal Plasma Concentrations Of Albendazole Sulfoxide
Electronics NEW ENERGY Audio Equipment Future-Concepts Psychology Science discover reality scientific hydraulic

Maximal Plasma Concentrations Of Albendazole Sulfoxide

ALBENZA (albendazole ) is an orally administered broad-spectrum anthelmintic

. Chemically, it is methyl 5-(propylthio)-2-benzimidazolecarbamate. Its molecular formula is C12H15N3O2S. Its molecular weight is 265.34.Albendazole is a white to off-white powder. It is soluble in dimethylsulfoxide, strong acids, and strong bases. It is slightly soluble in methanol, chloroform, ethyl acetate, and acetonitrile. Albendazole is practically insoluble in water. Each white to off-white, film-coated tablet contains 200 mg of albendazole tablets .

Inactive ingredients consist of: carnauba wax, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, povidone, sodium lauryl sulfate, sodium saccharin, sodium starch glycolate, and starch.

Albendazole is poorly absorbed from the gastrointestinal tract due to its low aqueous solubility. Albendazole concentrations are negligible or undetectable in plasma as it is rapidly converted to the sulfoxide metabolite prior to reaching the systemic circulation. The systemic anthelmintic activity has been attributed to the primary metabolite, albendazole sulfoxide. Oral bioavailability appears to be enhanced when albendazole is coadministered with a fatty meal (estimated fat content 40 g) as evidenced by higher (up to 5-fold on average) plasma concentrations of albendazole sulfoxide as compared to the fasted state.

Maximal plasma concentrations of albendazole sulfoxide are typically achieved 2 to 5 hours after dosing and are on average 1.31 mcg/mL (range 0.46 to 1.58 mcg/mL) following oral doses of albendazole (400 mg) in 6 hydatid disease patients, when administered with a fatty meal. Plasma concentrations of albendazole sulfoxide increase in a dose-proportional manner over the therapeutic dose range following ingestion of a fatty meal (fat content 43.1 g). The mean apparent terminal elimination half-life of albendazole sulfoxide typically ranges from 8 to 12 hours in 25 normal subjects, as well as in 14 hydatid and 8 neurocysticercosis patients.


Following 4 weeks of treatment with albendazole manufacturer (200 mg three times daily), 12 patients plasma concentrations of albendazole sulfoxide were approximately 20% lower than those observed during the first half of the treatment period, suggesting that albendazole may induce its own metabolism.

source:pharmaceutical-generic.blogtownhall

by: wenjun
Digital Tv Helps Channel 4 Put Up Brave Front To Recession 6 Things to Look For When Buying an Air Conditioner Confused while choosing your electricity provider? Read on to ease your efforts A Guide to Canon Power Shot Digital Camera There Is An Increased Risk Of Damage To The Plasma Cutter Aluminum Ladders Are Preferred By Many Craftsmen Differences Between The Electric Cello And The Electric Double-bass The Advantages of Consumer Reports Digital Camera Best Rated Digital Camera Top Pentax Digital SLR Camera Reviews! The Top JVC Digital Camcorder Models Industrial Cleaning Supplies: Keeping the Nation's Businesses Afloat Kodak digital camera an easy way to preserve vivid memories
print
www.yloan.com guest:  register | login | search IP(216.73.216.251) California / Anaheim Processed in 0.027026 second(s), 7 queries , Gzip enabled , discuz 5.5 through PHP 8.3.9 , debug code: 12 , 2858, 42,
Maximal Plasma Concentrations Of Albendazole Sulfoxide Anaheim