Oral vaccine developed in China par powers to speed up multiple positive growth - Vaccine research and development - pharmaceutical industries

Oral vaccine developed in China par powers to speed up multiple positive growth - Vaccine research and development - pharmaceutical industries

Recently, the National Science and Technology announced in Beijing, China with independent intellectual property rights of "oral recombinant Helicobacter pylori vaccine" has been successfully developed and obtained a class of new drug certificate.

Learned that the vaccine has good efficacy and safety, prevention of Helicobacter pylori infection rate of greater than 72.1% protection, can be produced in the gastrointestinal tract of high specific antibodies. Liu Yanhua, Vice Minister of Science and Technology

at a news conference, said: "This is by far the world's first complete Phase study of Helicobacter pylori oral vaccine." Marked the original vaccine research has made a major breakthrough.

Before this, China and some major breakthrough in vaccine development. March 21, the State Food And Drug Administration formally approved AIDS Phase clinical study vaccine launched in Guangxi. Also, the world's first diabetes oral vaccine only in recent days appeared in China. Some experts are optimistic that this year's vaccine R & D has multiple positive, vaccine research and development in China has entered the "fast lane."

However, some industry insiders believe, by capital, technology and other factors, our scientific research institutions in vaccine development against the background of prosperity, but also come a long bumpy road. The face of foreign vaccine manufacturers still empty, all kinds of infectious diseases Epidemic Become more complex, internal oral vaccine research and development added to the uncertainty.

Long way rough industrial "As the vaccine injections were orally inoculated with the traditional vaccination approach has many attractive advantages in comparison, therefore, our involvement with oral vaccine for some time, as experienced Helicobacter pylori vaccine is only 15 years of research development successful, it fills the birth of the field of vaccine development against stomach empty. From this sense, the oral vaccine vision can be expected. "Shanghai Fudan-Zhangjiang Bio Medicine In an interview with Vice President Dr. Su Yong Co., Ltd. "Medicine Economic News," reporters said. However, the "oral vaccine to achieve domestic industrial production there are still many technical problems to be broken." Despite the advantages of oral vaccine

more, but not all pathogens can be successfully used after the development of live attenuated oral vaccine. Life Sciences, Jilin University Vaccine Research Center Director, Professor Kong Wei carefully told reporters: "How to improve vaccine immunogenicity is a researcher insurmountable task. Not only in the mucosal surface to ensure adequate microbial survival time, but also to avoid side effects, balanced Both are still no precedent to follow, which can be in the dark, but we have reason to believe, no longer far away from the dawn. "

Interview, reporter learned that, in addition to the above-mentioned topics, the carrier materials research is also dense fog. "The use of carrier particles or nanoparticles Preparation of delivery system so popular though, but full of uncertainty. Like how to overcome the weaknesses of its poor water solubility and whether degradation is a very real problem." Microbiology and Immunology, Third Military Medical University, Laboratory of Microbiology and Immunology Director, also said: "The result is certainly encouraging, but this is only the first step Long March, the road ahead is still waiting to be reclaimed." Turning to industrial

roadblocks, the three veterans are referred to the current problem of low absorption of oral vaccine. It is understood, researchers try to use delivery system and mucosal adhesion targeting delivery system and other methods to improve the absorption of oral vaccine. "Now the research in animals has been successful, but whether it applies to the human body is unknown."

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