R & D Strategies Of Transnational Pharmaceutical Companies Frequently Adjust To Changes In The

With the constantly increasing difficulty of new drug development

, the major cross-border Pharmacy In new drug development strategy to make frequent adjustments to adapt to changing market conditions.

Recently, Eli Lilly and Company announced the global launch of a new R & D initiatives. Lilly will be invited to the field of global drug R & D scientists, to participate in Alzheimer's disease, Cancer , Diabetes and osteoporosis in the field of drug discovery.

This unique action known as "Eli Lilly and characterization of new drug R & D type (PhenotypicDrugDiscovery)", referred to as PD2. Researchers involved in the operation will use the gift to mature and the characterization of disease-related model-based drug screening, through a security portal, universities around the globe and biotechnology laboratory of biological compounds for analysis and characterization of type assessment. In this Cooperation -Generated research results will be the next Lilly collaboration with external research institutes or permits to reach the basis of business.

"Every year, researchers around the world will be at the university and the biotechnology laboratory designed and synthesized many new compounds, but often have no chance as potential drug candidates for a full assessment." Eli Lilly and Company Pharmaceutical Research and Development and Vice President of Technology Dr. Palkowitz about.

Learned that Lilly is not the first time researchers with external agencies such collaboration, but this time the action PD2 to researchers around the world to provide a more convenient way to participate in Lilly's drug research and development system to. In this way, those who have not previously worked with Eli Lilly and agencies and organizations can be more productive with the gift to establish the mutually beneficial cooperation. Dr.

Palkowitz: "Drug R & D innovation increasingly dependent on our extensive network established with the outside world." He said, PD2 is the Eli Lilly pharmaceutical company from a self-developed model to the cooperative R & D Medicine Another case of network transformation.

Researchers can in confidence, through the automated interface PD2 submit their chemical structure, by the computer system through proprietary algorithms Eli Lilly's drug-likeness of the compound and the structure of a preliminary calculation of novelty assessment. If the compound is consistent with a particular standard, the researchers will be invited to submit a physical sample for biological testing. All tests are provided free of charge Eli Lilly, and intellectual property rights remain with the stage of submission of all persons or organizations. PD2's objective is not to promote free to submit a large number of compounds, but to encourage diversity on the structure of a novel molecular biological characterization of a full type test. Dr

Palkowitz complete biological testing, Eli Lilly and Company will issue a data report the researchers, show that the four test compounds in the module (Alzheimer's disease, cancer, diabetes, osteoporosis) full biological activity in the test plan. These data are a complex system of systems biology models obtained, so the researchers can demonstrate to other than the current academic or government agencies a more comprehensive laboratory test results of the assessment of biological compounds.

Return for providing these data for the ceremony to their interest in further development of compounds with biological activity, Lilly will have to consult and cooperate with staff and submitted to the signing of an exclusive technology transfer agreement priority. If the two sides failed to reach agreement within the stipulated period, the researchers may not have any additional conditions to enjoy the ownership of the data report, and may choose to publish or conduct research fund for the application, or further optimize the molecular structure. All these activities will help promote the ultimate scientific discovery. Lilly PD2

participated in the development and testing of an expert is well-known University of Pittsburgh Professor of Chemistry and Pharmacy, Dr. PeterWipf. He said pharmaceutical companies who are not employed by the researchers, PD2 main advantage is that it can on the biological characterization of compounds in the mature type system for testing, to obtain comprehensive data related to the report, at the same time, there are opportunities and Eli Lilly of experts to exchange views of mutual interest and further compounds the idea.

by: gaga

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