The twelfth house in the astrological horoscope is where you will have the best chances to find inner peace. Much benefit can be gained from understanding this house which is ruled by Pisces. The house itself rules things behind the scene but each of the planets when occupying this house add a different meaning to the house.
The twelfth house is kind of a metaphysical house and rules the subconsciousness mind. For those of you who believe in karma brought forward from past lifetimes to this incarnation as either good or bad karmic lessons to be handled will have the potential to learn through this house. But your soul has also brought forward your gift and talents you have achieved in some of your past incarnations.
We may then assume that the subconscious mind holds the memories of souls previous lives and if that is so it would also have a strong influence on the health of your body. The house or sign which is in opposition to the twelfth house is in this case the sixth house which is very much associated with health. Houses which oppose each other help to bring balance to the other sign.
Mind, body and spirits needs to be in balance then your life works much better. With the planet Saturn in this house you may spend a lot of time in isolation it could either be as a patient or for service in a hospital. Or it could mean that you are working behind the scenes for some institution. It is important that people with this placement of Saturn make sure to adopt a positive attitude and not give into negative feelings.
Neptune which is in its natural house here signifies a powerful intuitive connection to the subconscious mind. A person with this placement quite often prefers privacy and seclusion so they can be in touch with their inner feelings. As you can see there can be quite a different interpretation regarding which planet is occupying the twelfth house.
In the horoscope of an artist or writer you will often find that the Sun is placed here. These people usually need a lot of quiet time spend alone where no one can disturb them. While the writer just want to quickly get his ideas down on paper or the artists are deeply involved in their work of art.