A better understanding of asbestos related diseases is necessary if we are ever to find a cure to Mesothelioma. One interesting study is called, Immunohistochemical localization of transforming growth factor beta isoforms in asbestos-related diseases. By J Jagirdar, T C Lee, J Reibman, L I Gold, C Aston, R Bgin, and W N Rom - Environ Health Perspect. 1997 September; 105(Suppl 5): 11971203. Here is an excerpt: Abstract - Transforming growth...more
Careful analysis of lung and mesothelial tissues must be done to determine the types of asbestos fibers associated with the mesothelioma One interesting study is called, Asbestos Fibers Contributing to the Induction of Human Malignant Mesothelioma by Yasunosuke Suzuki, Steven R. Yuen - Annals of the New York Academy of Sciences - Volume 982, Carcinogenesis Bioassays and Protecting Public Health: Commemorating The Lifework Of Cesare Maltoni And...more
We must focus our energy on finding a cure to Mesothelioma. It is a terrible disease and takes the lives of thousands every year. One interesting study is called, DNA single strand breaks induced by asbestos fibers in human pleural mesothelial cells in vitro by T. Ollikainen, K. Linnainmaa, and V.L. Kinnula - Environmental and Molecular Mutagenesis - Volume 33, Issue 2, pages 153160, 1999. Here is an excerpt: Abstract - The mechanisms of the cellular effects and DNA damage caused by asbestos fibers in human mesothelial cells are not well understood. We exposed transformed human pleural mesothelial cells to 14 g/cm2 crocidolite and to 10100 ng/ml tumor necrosis factor alpha for up to 48 hr and studied the induction of DNA damage using the Comet assay. As a positive control, 100 M H2O2 was used. The DNA single strand breaks were assessed as the mean tail moments and as distributions of the tail DNA in the cell. The Comet assay showed significant but reversible increases in the mean tail moments, but not in the distribution of Comet tails in the histograms in cells exposed to 1 g/cm2 crocidolite for 6 hr. At higher concentrations of asbestos fibers all the indices in the Comet...more
Exposure to asbestos in the workplace is the most common cause of Mesothelioma disease. Continued research is necessary if we are ever to find a cure. One interesting study is called, Exposure to Asbestos and Human Disease. By Becklake, MR - New England Journal of Medicine Vol. 306, no. 24, pp. 1480-1482. 1982. Here is an excerpt: During the...more
Asbestos is something which most people in the UK are familiar with. Asbestos was at one time used as a building materiel due to its heat resistance properties and strength. Asbestos can actually be quite hazardous to the health. The dangers of asbestos had not been identified for years and asbestos related disease takes many years to...more
Mesothelioma deaths among workers is a sad part of this countrys history. However, there is some important research being done regarding asbestos and its complications. One interesting study is called, Asbestos-induced sister chromatid exchanges in cultured Chinese hamster ovarian fibroblast cells. By Livingston GK, Rom WN, Morris MV. - J Environ Pathol Toxicol. 1980 Sep;4(2-3):373-82. Here is an excerpt: Abstract - Asbestos fibers were tested for possible mutagenic activity using the Fluorescent Plus Giemsa (FPG) sister chromatid exchange (SCE) technique. Amosite, crocidolite, and chrysotile fibers were added to cell cultures at final concentrations of 10 and 100 micrograms/ml. Chrysotile completely inhibited cell growth at both concentrations; cells exposed to amosite and crocidolite proliferated but only at the lower concentration. Crocidolite significantly elevated the SCE rate and larger (greater than 5 mu) chromosomes were most sensitive. Amosite appeared to have a lesser effect on SCE frequency. Asbestos fibers are capable of disturbing cellular processes associated with chromosomal stability and effects vary with the asbestos type.Another interesting study is called,...more
Asbestos exposure has been deadly to many people in the past decades. There is a mountain of important literature and research done on this area. One interesting study is called, Mortality from lung cancer and population risk attributable to...more
Who can argue with the facts, exposure to hazardous asbestos can be fatal. Serious doctors have reached a consensus thanks in large part to the myriad of studies researching Mesothelioma and its causes. One interesting study is called, Ecological...more
Disease development among people exposed to hazardous asbestos has been carefully studied over the years. One interesting study is called, Squamous metaplasia of the respiratory tract. Possible pathogenic role in asbestos-associated bronchogenic...more
A better understanding of asbestos disease such as Mesothelioma is required if we are ever going to make progress in the search for a cure. One interesting study is called, Asbestos fibers and pleural plaques in a general autopsy population. By A....more
Asbestos seems to have high potency in the carcinogenesis of lung cancer and low potency in carcinogenesis of Mesothelioma. One interesting study is called, Asbestos and cigarette smoke cause increased DNA strand breaks and necrosis in bronchiolar...more
Asbestos workers have been plagued with mesothelioma and other diseases for some time now, and continued vigilance is required if we are ever to solve this problem. One interesting study is called, 'B-Readers' and Asbestos Medical Surveillance by...more