July price cuts, "stick" under the third and fourth generation cephalosporins future - the pharmaceutical industry

July price cuts, "stick" under the third and fourth generation cephalosporins future - the pharmaceutical industry

Learned, early in July, the NDRC's price cut, "stick" will once again command the Antibiotic In the field, this is the third encounter of antibiotics enterprises cut prices to make. Cephalosporin Streptomyces is a major force in the field of antibiotics, can not cut prices in the natural immune. At present, a time when the third and fourth generation cephalosporins to grow and the occasion, price reduction trend is irreversible, the third and fourth generation cephalosporins in turn how the future development of face? Cephalosporins product chain of production with corn as the raw material first be Starch And liquid sugar, then top cephalosporin bacteria and their descendants for the bacteria to be the natural fermentation of cephalosporin C as the raw material, and then synthesized to 7-ACA, via semi-synthesis through the transformation of their side chains which are different. Cephalosporins have become the temporary Bed Commonly used antibiotics, mainly due to penicillin cephalosporins not only has similar fine Pharmacology Characteristics, and low toxicity, broad indications of clinical needs such as better suited to the advantages, such as resting and aminoglycoside combination fungicides can often get a good synergy. It is because of these advantages, making the field of cephalosporin antibiotics into the star species, occupied a considerable market share of antibiotics and the development momentum. First, the second-generation cephalosporins now widely accepted by the market, while the third, fourth generation cephalosporins are at the stage of the export market development. Third-generation cephalosporins: a glorious future The emergence of third-generation cephalosporins, antimicrobial spectrum to make further resistance, resistance has also been enhanced enzyme, although Leather Gram positive bacteria antimicrobial performance is generally lower than the first generation (similar to individual species), but the role of Gram-negative bacteria compared to the second-generation cephalosporin was more superior. It is because of third-generation cephalosporins Clinical Excellence Table Is made to Ceftazidime and ceftriaxone as the representative for the rapidly growing third-generation cephalosporin cephalosporin antibiotics on the market and even the star variety. Amount of third-generation cephalosporin market, the rapid growth in the 21st century reflects more marked, such as ceftriaxone, has been developed to the annual consumption of 1000 tons of raw materials on the scale, and ceftazidime also showed the acceleration of development. The root of the root causes, in addition to the excellent quality of the product itself, but also as clinical excellence, gradually enlarge the market makes API , Preparation Rapidly falling prices are not unrelated. Security Is the basis, quality is life, cost-effective, I believe this view is shared by the industry. The third-generation cephalosporins, ceftriaxone or ceftazidime, whether in today's market is the best example of excellent performance. Fourth-generation cephalosporins: a downturn in As third-generation cephalosporins against Gram-positive bacteria the role of weak and can not be used to control Staphylococcus aureus infection, therefore, cefpirome, Cefozopran, cefepime and other fourth-generation cephalosporins should be shipped born. Fourth-generation cephalosporins in clinically serious bacterial infections than most third-generation cephalosporins better results, such as cefpirome, not only maintained a third-generation cephalosporins on the powerful role of gram-negative bacteria, but also enhance Gram-positive bacteria, antimicrobial activity and to avoid breakthrough drug resistance, especially Streptococcus , Pneumococcus has a strong activity against Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus also has antibacterial activity. It is because of fourth-generation cephalosporins clinical excellence, as well as antibiotics, "noble" varieties of Status, in order to stimulate R & D to operate from the terminal as well as the use of stable growth. However, due to its domestic and international market competition is not sufficient, in particular manufacturers API is still very limited, resulting in the production costs of this species was once high. More severe, these noble varieties is done once the clinical variety, a certain sense, all aspects of the corresponding high cost. Now people in the "medical treatment difficult and expensive," under the strong voice in the government building a harmonious social atmosphere, these noble varieties once again Hospital The "avoid arousing suspicion" variety. Therefore, the fourth-generation cephalosporins in clinical use encounters strong block. This "awkward" situation, and can not rely on bulk drug price cuts of several thousand dollars per kilogram can be solved. Can see that the fact that: cefpirome offer, from the 56th Chengdu API pre's 12,000 yuan / kg to 8,500 after the yuan / kg, up to 30% price cut, but the substantial price reductions not because of raw material between drug manufacturers bidding each other, but because the terminal agent market downturn. Therefore, at this time that failed to achieve the ultimate decline of the lowest-volume manufacturers would like to see rise situation. Can say is that, like the fourth-generation cephalosporins are still tall these advanced prices of antibiotics, in today's suppressed by the strong force would be unprecedented, development and production of its new series of acts will undoubtedly enter downturn. In the long term, this will greatly reduce the abuse of antibiotics and advanced use of the phenomenon, the development of human health. On the other hand to consider, many of the appropriate agents and even drug manufacturers of raw materials and R & D business development unit will be temporarily affected. In short, the development of fourth generation cephalosporins are still to, the outlook is very confused. Comment Large In Small

POST COMMENT

The Video Wall: Step Into the Future With Interactive Technology Biodiesel- The fuel of the future Beekeeping Help for Future Beekeepers There's a Way to Improve Your Future: Obama Scholarships for Moms Organizations need to keep up with future trends Let's Improve Your Future: Obama Scholarships For Moms An Investment for Our Future: Obama Grants for Moms Obama Scholarships For Moms: There's A Way To Improve Your Future Obama Scholarships for Moms: There's Money to Improve Your Future Will The Reusable Alkaline Battery Have A Future? Succession Planning: How to Meet Future Talent Needs Future Leaders In Philanthropy - Everything About The Project And Aims Can Cloud Apps Replace Desktops In The Future?