Experts Said The New Stent To Increase The Treatment Of Complex Medical Patient To Grasp - Stent,

2008 10 24 - International Conference Centre in Beijing at the 19th Great Wall

International Heart disease Studies Conference, experts with the new Medtronic stent EndeavorSprint example pointed out that the support the latest transmission technology used to make the patient during surgery to reduce the endothelial damage and sometimes can not stand because the old economic losses caused by the same time, Medical treatment of complex lesions increase the patient's grasp, increase efficiency. Its high biological compatibility of drug carrier, the greatly reduced incidence of delayed thrombosis.

Vice president of the Shenyang Military Region General Hospital and Professor Han Yaling, director of Cardiology at the meeting pointed out that stenting is a successful stent implantation in the first step. Medtronic stent EndeavorSprint new drugs through the use of balloon material softer, more flexible tip design and the adoption of a smaller diameter to further improve the transmission performance. For patients, such a stent delivery system means less damage to the endothelium, but also reduces the stent can not be certain because of complex economic loss caused by disease; For doctors, this means increasing the treatment of complicated lesions grasp, such as diabetes, tortuous bending and a high degree of calcification, etc.; the same time, the push rod is conducive to improving the bifurcation lesions (split ends took place in the vascular lesion, surgery is complicated and demanding on the equipment), and the radial Artery surgery operation.

In drug-eluting stent system, the polymer carrier is carrying drugs, able to combine drug and stent platform, while the efficacy of the drug, the drug concentration in the control and release also play a role . On the measure of long-term safety of drug stents, the Fu Wai Hospital, vice president, cardiovascular disease expert Professor Yang Yuejin that polymer scaffolds for long-term safety is important. A series of animal experiments and clinical studies have shown that the first generation drug-eluting stents used in parts of polymer scaffold resulted in local inflammation and hypersensitivity, which is poor tissue biocompatibility, affecting the normal healing of vascular endothelial cells, that endothelialization. Delayed and incomplete endothelialization leading to late thrombosis reasons. What

polymer that is ideal? Professor Yang Yuejin that biocompatibility, that is, does not lead to rejection. Biocompatibility includes three aspects: hydrophilic, non-induced inflammation caused by inflammatory cells that is not easy to gather, non-thrombotic origin that is not easy to form blood clots. Biocompatibility of polymer can be normal vascular repair: the rapid, complete, functional well-endothelialization.

Example, the second-generation drug-eluting stents EndeavorSprint the polymer is a PC (phosphorylcholine) technology, PC simulation of the red blood cell membrane structure, with a high degree of biocompatibility, the use of strong and can cover flexible cobalt alloy stent on the unique module. This structure makes the support of the trunk is extremely smooth and thin, which will stand securely wrapped with the blood flow in the artery wall separated. And other drug-eluting stents compared to polymers, PC most hydrophilic, resulting in inflammatory and thrombotic derived minimum, animal models and clinical study results also show that the degree of Endeavor endothelium and endothelial function in the best. Endeavor's late thrombosis rate (one year later) was significantly lower than the first-generation drug-eluting stent; the same time, again likely to remain at a low level operation, there is no "late catch-up" phenomenon, which occurred one year after surgery the patient clinical symptoms likely to be very low re-operation. In contrast, by 2005 the older generation in China, support the listing of a "late catch-up" phenomenon more.

Experts believe that, EndeavorSprint stent also has excellent safety and efficacy data, the high degree of biocompatibility of PC technology has played a vital role, but also to the future development of a new generation of drug-eluting stents that direction.

"The advent of drug stents to solve the original bare metal stent restenosis rate of the problem, therefore, obvious effect. And EndeavorSprint support, not only to highlight the effect, but also addresses late stent thrombosis than bare metal stents slightly higher rate security issues. and easy to transport, less traumatic for patients, doctors, deal with more complex lesions grasp.

by: gaga

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